Antenatal Late Preterm Steroids: The Evolution of the ALPS Trial.

Clin Obstet Gynecol

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, University of California, La Jolla, California.

Published: June 2024

AI Article Synopsis

  • The Antenatal Late Preterm Steroids (ALPS) trial aimed to reduce respiratory issues in infants born late preterm and was published in April 2016, significantly impacting obstetric practices in the U.S.
  • The chapter provides an in-depth look at the trial's design, background, outcomes, and long-term follow-up findings.
  • It also honors Elizabeth Thom, PhD, whose key contributions to the trial's design are recognized despite her untimely passing.

Article Abstract

The Antenatal Late Preterm Steroids (ALPS) trial was designed to address respiratory morbidity common in infants born late preterm. The study was published in April, 2016 and, shortly thereafter, changed clinical practice in obstetrics in the United States. The following chapter describes the ALPS trial study design in detail, including the background leading to the trial, the study outcomes, and the initial findings of the long-term follow-up study. The ALPS story would not be complete without Elizabeth Thom, PhD, who died before her time. Her brilliance largely contributed to the design of the ALPS trial.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068095PMC
http://dx.doi.org/10.1097/GRF.0000000000000865DOI Listing

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