Hydrothermally prepared copper-doped carbon dots (Cu-CDs) were modified with Ca, which serve as an excellent platform for the recognition of glycine. The feeble emission of Ca@Cu-CD increases substantially in the presence of glycine due to aggregation-induced emission. At the same time, there was a 5-fold increase in the current response of the Ca@Cu-CD modified electrode as compared to the control. The exceptional combination of fluorescence and conducting properties, along with Ca-glycine interaction, establishes our probe as a dual sensor for the detection of glycine in real serum samples. The limit of detection for this nonenzymatic fluorescence and electrochemical sensing are 17.2 and 4.1 nM, respectively. Furthermore, an extensive evaluation of the toxicity and bioimaging properties in fruit fly shows that the Ca@Cu-CD probe is not cytotoxic and can be applied for imaging of glycine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4tb00060a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Advancing dynamic quantum crystallography: enhanced models for accurate structures and thermodynamic properties.
IUCrJ
January 2025
Faculty of Chemistry, University of Warsaw, Pasteura 1, Warsaw, 02-093, Poland.
X-ray diffraction (XRD) has evolved significantly since its inception, becoming a crucial tool for material structure characterization. Advancements in theory, experimental techniques, diffractometers and detection technology have led to the acquisition of highly accurate diffraction patterns, surpassing previous expectations. Extracting comprehensive information from these patterns necessitates different models due to the influence of both electron density and thermal motion on diffracted beam intensity.
View Article and Find Full Text PDFExamination of the Bioavailability and Bioconversion of Wheat Bran-Bound Ferulic Acid: Insights into Gastrointestinal Processing and Colonic Metabolites.
J Agric Food Chem
January 2025
School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, 430023, China.
The postingestion journey and bioconversion of wheat bran-bound ferulic acid, a known beneficial phytochemical, remain insufficiently understood. This study aims to systematically investigate its bioaccessibility, bioavailability, excretion, and colonic metabolism, both and . Initial analysis confirmed the abundance and bioactivity of ferulic acid in wheat bran.
View Article and Find Full Text PDFApplication of integrated omics in aseptic loosening of prostheses after hip replacement.
Mol Med Rep
March 2025
Department of Orthopedics, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
Aseptic loosening (AL) of artificial hip joints is the most common complication following hip replacement surgery. A total of eight patients diagnosed with AL following total hip arthroplasty (THA) undergoing total hip replacement and eight control patients diagnosed with avascular necrosis of femoral head (ANFH) or femoral neck fracture undergoing THA were enrolled. The samples of the AL group were from synovial tissue surrounding the lining/head/neck of the prosthesis, and the samples of the control group were from the synovium in the joint cavity.
View Article and Find Full Text PDFBiallelic Variant in the AGXT Gene in a Family Segregating Primary Hyperoxaluria; Accurate Genetic Diagnosis and Carrier Detection.
Nephrology (Carlton)
January 2025
Center for Genetics and Inherited Diseases, Taibah University Medina, Madinah, Kingdom of Saudi Arabia.
Aim: Autosomal recessive primary hyperoxalurias (PH) are genetic disorders characterised by elevated oxalate production. Mutations in genes involved in glycoxylate metabolism are the underlying cause of PH. Type 1 PH (PH1) results in malfunctioning of alanine-glyoxylate aminotransferase enzymes of liver due to a change in the genetic sequence of alanine-glyoxylate aminotransferase (AGXT) gene.
View Article and Find Full Text PDFIdentification of a novel mutation in the gene in low phytate Basmati rice mutant and development of CAPS marker for marker-assisted breeding.
Front Plant Sci
December 2024
State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Low phytate level is a desirable trait because it promotes mineral bioavailability and thus offers a solution to tackle mineral deficiencies. The objectives of the present study were to characterize low phytate (lpa) Basmati rice mutants for the identification of novel mutations in target gene(s) and to develop a PCR-based CAPS (cleaved amplified polymorphic sequence) marker for low phytate Basmati rice. For this purpose, cultivar Super Basmati (Q4) was irradiated with gamma rays (Co source) and three mutants named Q1 (lpa-5-9), Q2 (lpa-9-13), and Q3 (lpa-59-14) were isolated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!