SPRY4 is a protein encoding gene that belongs to the Spry family. It inhibits the mitogen-activated protein kinase (MAPK) signaling pathway and plays a role in various biological functions under normal and pathological conditions. The SPRY4 protein has a specific structure and interacts with other molecules to regulate cellular behavior. It serves as a negative feedback inhibitor of the receptor protein tyrosine kinases (RTK) signaling pathway and interferes with cell proliferation and migration. SPRY4 also influences inflammation, oxidative stress, and cell apoptosis. In different types of tumors, SPRY4 can act as a tumor suppressor or an oncogene. Its dysregulation is associated with the development and progression of various cancers, including colorectal cancer, glioblastoma, hepatocellular carcinoma, perihilar cholangiocarcinoma, gastric cancer, breast cancer, and lung cancer. SPRY4 is also involved in organ development and is associated with ischemic diseases. Further research is ongoing to understand the expression and function of SPRY4 in specific tumor microenvironments and its potential as a therapeutic target.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11056578 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1376873 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oligogenic analysis across broad phenotypes of 46,XY differences in sex development associated with NR5A1/SF-1 variants: findings from the international SF1next study.
EBioMedicine
March 2025
Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland; Department for BioMedical Research, University of Bern, Bern 3008, Switzerland. Electronic address:
Background: Oligogenic inheritance has been suggested as a possible mechanism to explain the broad phenotype observed in individuals with differences of sex development (DSD) harbouring NR5A1/SF-1 variants.
Methods: We investigated genetic patterns of possible oligogenicity in a cohort of 30 individuals with NR5A1/SF-1 variants and 46,XY DSD recruited from the international SF1next study, using whole exome sequencing (WES) on family trios whenever available. WES data were analysed using a tailored filtering algorithm designed to identify rare variants in DSD and SF-1-related genes.
A heterozygous SPRY4 variant identified in female infertility characterized by reduced oocyte potential and early embryonic arrest.
Hum Reprod
November 2024
Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Pharmacy School, Fudan University, Shanghai, PR China.
Article Synopsis
- Scientists found a specific gene variant called SPRY4 in women who have trouble getting pregnant, which could help explain some cases of infertility.
- They studied how this gene works in the body and found it's really important for female reproductive health.
- Before this study, no one had linked this gene to female fertility issues, so their discovery could lead to better understanding and treatments for infertility.
SPRY4 regulates ERK1/2 phosphorylation to affect oxidative stress and steroidogenesis in polycystic ovary syndrome.
Steroids
December 2024
Reproductive Medicine Center, Northern Jiangsu People's Hospital, Yangzhou City, Jiangsu Province 225000, China. Electronic address:
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of childbearing age. The role of Sprouty RTK Signaling Antagonist 4 (SPRY4) in ovarian function in PCOS was investigated herein, focusing on its regulation of ERK1/2 phosphorylation. PCOS models were established in mice using dehydroepiandrosterone (DHEA).
View Article and Find Full Text PDFASCL1 Restrains ERK1/2 to Promote Survival of a Subset of Neuroendocrine Lung Cancers.
Mol Cancer Ther
December 2024
Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas.
The transcription factor achaete-scute complexhomolog 1 (ASCL1) is a lineage oncogene that is central in growth and survival of the majority of small cell lung cancers and neuroendocrine (NE) non-small cell lung cancers (NSCLC) that express it. Targeting ASCL1, or its downstream pathways, remains a challenge. Small cell lung cancers and NSCLC-NE that express ASCL1 exhibit relatively low ERK1/2 activity, in dramatic contrast to NSCLCs in which the ERK pathway plays a major role in pathogenesis.
View Article and Find Full Text PDFMultiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice.
Sci Rep
August 2024
Developmental and Oncogenic Signaling Group, Edifici Biomedicina I, Lab 2.8, Department of Experimental Medicine, Universitat de Lleida/Institut de Recerca Biomèdica de Lleida, Rovira Roure, 80, 25198, Lleida, Spain.
Article Synopsis
- The Sprouty genes (Spry1-4) inhibit receptor tyrosine kinases and play important roles in embryo development and tumor suppression in adults.* -
- Research involving adult-onset triple knockout mice for Spry1, Spry2, and Spry4 shows that while these mice experience various health issues, like weight loss and endocrine abnormalities, they do not have an increased incidence of tumors compared to normal mice.* -
- Findings suggest that the loss of Sprouty genes may impact metabolic and endocrine functions without necessarily leading to tumor development.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!