Introduction: We report a case of refractory overactive bladder with cough-associated detrusor overactivity treated by onabotulinumtoxin A.
Case Presentation: A 79-year-old woman who underwent mid-urethral sling surgery 8 years ago complained mainly of urinary incontinence following abdominal pressure. Various medicines to treat overactive bladder symptoms were ineffective. Cystometry revealed cough-associated detrusor overactivity. Onabotulinumtoxin A injections in her bladder improved subjective symptoms, and cough-associated detrusor overactivity disappeared on cystometry.
Conclusions: Onabotulinumtoxin A injection effectively resolved refractory overactive bladder with urgency urinary incontinence due to cough-associated detrusor overactivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11056263 | PMC |
| http://dx.doi.org/10.1002/iju5.12716 | DOI Listing |
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Introduction: We report a case of refractory overactive bladder with cough-associated detrusor overactivity treated by onabotulinumtoxin A.
Case Presentation: A 79-year-old woman who underwent mid-urethral sling surgery 8 years ago complained mainly of urinary incontinence following abdominal pressure. Various medicines to treat overactive bladder symptoms were ineffective.
Efficacy of combination therapy of mid-urethral sling and low-dose Abobotulinumtoxin-A injection in mixed urinary incontinence.
Neurourol Urodyn
January 2022
Bristol Urological Institute, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
Objectives: To determine the outcome of combined transobturator tape sling (TOT) and low dose intradetrusor injection of Abobotulinumtoxin-A (Abobot-A, Dysport®) in women with mixed urinary incontinence (MUI).
Methods: This randomized, active comparator-controlled, parallel-group, two-part clinical trial was conducted on women who had positive Valsalva leak point pressure (VLPP) + detrusor overactivity (DO), cough-associated DO. In Part 1, 20 women with MUI who had a failure of medical and behavioral therapies to cure MUI, randomized in two groups receiving TOT surgery alone, or in combination with Dysport® injection (n = 10 in each group), and then Part 2 was initiated as a prospective open-label on 40 more patients.
Cough associated detrusor overactivity in women with urinary incontinence.
Neurourol Urodyn
March 2019
Department of Urology, Apollo Hospitals, Hyderabad, India.
Aims: This is the first study that attempts to define different forms of cough associated detrusor overactivity (CADO). Current literature lacks clarity regarding the types of CADO and clinical epidemiology.
Methods: Retrospective review of all adult women who underwent urodynamics for urinary incontinence (UI) over 7 years.
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