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Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review. | LitMetric

AI Article Synopsis

  • Proton pump inhibitors (PPIs) are commonly used to treat conditions like stomach ulcers and GERD in kids over 1 year old, but their long-term use can lead to side effects.
  • A review of 30 studies involving over 762,000 pediatric patients found that 6.98% experienced adverse effects, with respiratory and gastrointestinal issues being the most frequent.
  • It is important for doctors to prescribe PPIs only when necessary and to educate patients about the potential risks associated with these medications.

Article Abstract

Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057350PMC
http://dx.doi.org/10.1177/2333794X241248967DOI Listing

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