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General anesthesia induces acute cell-free DNA methylation changes in peripheral blood.
J Thorac Dis
November 2024
Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, China National Center for Respiratory Medicine, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, China.
Background: Short-term and long-term adverse events could occur after general anesthesia (GA) and the specific mechanism driving these effects has not yet been well-characterized. In this study, we aimed to evaluate the global effect of GA on DNA methylation in the cell-free DNA (cfDNA) of surgical lung-nodule patients.
Methods: This large retrospective cohort study enrolled 1,006 surgical lung nodule patients (529 pre-anesthesia, and 477 post-anesthesia).
Effect of peimisine on pulmonary interstitial fibrosis induced by bleomycin in mouse pulmonary fibrosis.
Pak J Pharm Sci
September 2024
School of Pharmacy, Guangdong Food and Drug Vocational College, China.
Peimisine has therapeutic effects on cough, asthma, acute lung injury and liver fibrosis. However, it has not been reported whether peimisine has an inhibitory effect on pulmonary fibrosis. In current study, a mouse pulmonary interstitial fibrosis model was established to investigate the efficacy of peimisine.
View Article and Find Full Text PDFNeutrophil extra-cellular traps in blood during the response to Acinetobacter infection following chemotherapy.
Br J Haematol
July 2024
Department of Pediatrics, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Hyogo, Japan.
Toll-like Receptors as Pro-Thrombotic Drivers in Viral Infections: A Narrative Review.
Cells
July 2023
Division of Angiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Toll-like receptors (TLRs) have a critical role in the pathogenesis and disease course of viral infections. The induced pro-inflammatory responses result in the disturbance of the endovascular surface layer and impair vascular homeostasis. The injury of the vessel wall further promotes pro-thrombotic and pro-coagulatory processes, eventually leading to micro-vessel plugging and tissue necrosis.
View Article and Find Full Text PDFCirculating "Neutrophils extra-cellular traps" during the early post-renal transplant period and correlation with graft dysfunction and rejection.
Transpl Immunol
October 2023
Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Background: Neutrophil extracellular traps (NETs) have a role in infection, autoimmunity, autoinflammation, thrombosis, ischemia-reperfusion injury (IRI), epithelial-mesenchymal transition, vasculitis, and metabolic diseases. However, its role in early graft injury and graft outcome has not been elucidated till now. We evaluated the circulating NETs during early post-transplant periods and their correlation with graft outcome and IRI.
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