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Associations between short-term exposure to air pollution and thyroid function in a representative sample of the Korean population. | LitMetric

AI Article Synopsis

  • The study investigates the link between short-term air pollution exposure and thyroid function, addressing a gap in research mainly focused on pregnant women.
  • Analyzing data from over 5,600 participants, findings reveal that increased levels of nitrogen monoxide (NO) and carbon monoxide (CO) correlate with higher thyroid-stimulating hormone (TSH) levels, while particulate matter (PM) and ozone (O) exposure is linked to lower free thyroxine (fT4) levels.
  • The authors emphasize that even subtle changes in thyroid function can impact overall health, highlighting the need for further research to validate these findings due to the cross-sectional nature of the study.

Article Abstract

Background: Disruption of thyroid function can profoundly affect various organ systems. However, studies on the association between air pollution and thyroid function are relatively scarce and most studies have focused on the long-term effects of air pollution among pregnant women.

Objectives: This study aimed to explore the associations between short-term exposure to air pollution and thyroid function in the general population.

Methods: Data from the Korea National Health and Nutrition Examination Survey (2013-2015) were analyzed (n = 5,626). Air pollution concentrations in residential addresses were estimated using Community Multiscale Air Quality models. The moving averages of air pollution over 7 days were set as exposure variables through exploratory analyses. Linear regression and quantile g-computation models were constructed to assess the effects of individual air pollutants and air pollution mixture, respectively.

Results: A 10-ppb increase in NO (18.8-μg/m increase) and CO (11.5-μg/m increase) was associated with 2.43% [95% confidence interval (CI): 0.42, 4.48] and 0.19% (95% CI: 0.01, 0.36) higher thyroid-stimulating hormone (TSH) levels, respectively. A 10-μg/m increase in PM and a 10-ppb increase in O (19.6-μg/m increment) were associated with 0.87% (95% CI: 1.47, -0.27) and 0.59% (95% CI: 1.18, -0.001) lower free thyroxine (fT4) levels, respectively. A simultaneous quartile increase in PM, NO, O, and CO levels was associated with lower fT4 but not TSH levels.

Conclusions: As the subtle changes in thyroid function can affect various organ systems, the present results may have substantial public health implications despite the relatively modest effect sizes. Because this was a cross-sectional study, it is necessary to conduct further experimental or repeated-measures studies to consolidate the current results.

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Source
http://dx.doi.org/10.1016/j.envres.2024.119018DOI Listing

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