Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586687 | PMC |
| http://dx.doi.org/10.1002/chem.202401214 | DOI Listing |
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