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The modification landscape of tRNAs. | LitMetric

The modification landscape of tRNAs.

RNA

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA

Published: July 2024

AI Article Synopsis

Article Abstract

RNA modifications have a substantial impact on tRNA function, with modifications in the anticodon loop contributing to translational fidelity and modifications in the tRNA core impacting structural stability. In bacteria, tRNA modifications are crucial for responding to stress and regulating the expression of virulence factors. Although tRNA modifications are well-characterized in a few model organisms, our knowledge of tRNA modifications in human pathogens, such as , remains limited. Here, we leveraged two orthogonal approaches to build a reference landscape of tRNA modifications in , which enabled us to identify similar modifications in Our analysis supports a substantial degree of conservation between the two organisms, while also uncovering potential sites of tRNA modification in tRNAs that are not present in The mutational signature at one of these sites, position 46 of tRNA is dependent on the homolog of TapT, the enzyme responsible for the 3-(3-amino-3-carboxypropyl) uridine (acpU) modification. Identifying which modifications are present on different tRNAs will uncover the pathways impacted by the different tRNA-modifying enzymes, some of which play roles in determining virulence and pathogenicity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251520PMC
http://dx.doi.org/10.1261/rna.080004.124DOI Listing

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