AI Article Synopsis
- Viruses, particularly nuclear replicating ones like herpesviruses and adenoviruses, have evolved ways to hijack host cell functions effectively, showcasing their role as molecular biologists.
- The review highlights critical components of nuclear architecture, such as chromatin and the nucleolus, to explain the ongoing conflict between viruses and host cells for nuclear resources.
- Finally, it discusses recent technological advances that have facilitated these discoveries and outlines future directions in the study of nuclear replicating viruses.
Article Abstract
Viruses are exemplary molecular biologists and have been integral to scientific discovery for generations. It is therefore no surprise that nuclear replicating viruses have evolved to systematically take over host cell function through astoundingly specific nuclear and chromatin hijacking. In this review, we focus on nuclear replicating DNA viruses-herpesviruses and adenoviruses-as key examples of viral invasion in the nucleus. We concentrate on critical features of nuclear architecture, such as chromatin and the nucleolus, to illustrate the complexity of the virus-host battle for resources in the nucleus. We conclude with a discussion of the technological advances that have enabled the discoveries we describe and upcoming steps in this burgeoning field.
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| http://dx.doi.org/10.1146/annurev-virology-100422-011616 | DOI Listing |
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