Given the radiobiological and physical properties of the proton, proton beam therapy has the potential to be advantageous for many patients compared with conventional radiotherapy by limiting toxicity and improving patient outcomes in specific breast cancer scenarios.
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Proton arc therapy plan optimization with energy layer pre-selection driven by organ at risk sparing and delivery time.
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Center for Molecular Imaging and Experimental Radiotherapy, Universite Catholique de Louvain, av Hippocrate 55 B1.54.07, Brussels, 1200, BELGIUM.
Objective: As proton arc therapy (PAT) approaches clinical implementation, optimizing treatment plans for this innovative delivery modality remains challenging, especially in addressing arc delivery time. Existing algorithms for minimizing delivery time are either optimal but computationally demanding or fast but at the expense of sacrificing many degrees of freedom. In this study, we introduce a flexible method for pre-selecting energy layers (EL) in PAT treatment planning before the actual robust spot weight optimization.
View Article and Find Full Text PDFIPEM code of practice for proton therapy dosimetry based on the NPL primary standard proton calorimeter calibration service.
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Radiotherapy and Radiation Dosimetry group, National Physical Laboratory, Hampton Road, Middlesex, Teddington, TW11 0LW, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Internationally, reference dosimetry for clinical proton beams largely follows the guidelines published by the International Atomic Energy Agency (IAEA TRS-398 Rev. 1, 2024). This approach yields a relative standard uncertainty of 1.
View Article and Find Full Text PDFToxicity and Quality of Life After Locoregional Radiotherapy in Patients With Thyroid Cancer.
Head Neck
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Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
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View Article and Find Full Text PDFPrognostic Value of Pretreatment Carcinoembryonic Antigen (CEA) in Rectal Cancer Treated with Preoperative Short-Course Radiotherapy with Delayed Surgery or Long-Course Radiotherapy.
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Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, 833, Taiwan.
Purpose: To investigate the prognostic value of the pretreatment serum carcinoembryonic antigen (CEA) level in patients with rectal cancer treated by preoperative short-course radiotherapy (SCRT) followed by chemotherapy and delayed surgery.
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Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness.
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January 2025
Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.
Background And Purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose. However, RBE varies with tissue type, fraction dose, and beam quality parameters beyond dose such as linear energy transfer (LET) raising concerns about increased local effectiveness and potential toxicity.
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