AI Article Synopsis
- * Chronic intestinal conditions, such as inflammatory bowel diseases (IBD), involve imbalances in gut microbiota and ongoing inflammation, which probiotics may help address.
- * Recent studies analyze how probiotics positively affect gut health through mechanisms like eliminating harmful pathogens, providing protective substances, and supplying essential nutrients.
Article Abstract
Probiotics are live microorganisms exerting beneficial effects on the host's health when administered in adequate amounts. Among the most popular and adequately studied probiotics are bacteria from the families , and yeasts. Most of them have been shown, both and studies of intestinal inflammation models, to provide favorable results by means of improving the gut microbiota composition, promoting the wound healing process and shaping the immunological responses. Chronic intestinal conditions, such as inflammatory bowel diseases (IBD), are characterized by an imbalance in microbiota composition, with decreased diversity, and by relapsing and persisting inflammation, which may lead to mucosal damage. Although the results of the clinical studies investigating the effect of probiotics on patients with IBD are still controversial, it is without doubt that these microorganisms and their metabolites, now named postbiotics, have a positive influence on both the host's microbiota and the immune system, and ultimately alter the topical tissue microenvironment. This influence is achieved through three axes: (1) By displacement of potential pathogens competitive exclusion; (2) by offering protection to the host through the secretion of various defensive mediators; and (3) by supplying the host with essential nutrients. We will analyze and discuss almost all the and studies of the past 2 years dealing with the possible favorable effects of certain probiotic genus on gut immunological responses, highlighting which species are the most beneficial against intestinal inflammation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045475 | PMC |
| http://dx.doi.org/10.3748/wjg.v30.i15.2096 | DOI Listing |
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