AI Article Synopsis
- Juvenile myelomonocytic leukemia (JMML) is a complex blood disorder found mainly in infants and young children, where both overproduction and abnormal development of blood cells occur.
- Current methods for predicting patient outcomes in JMML are inadequate, leading researchers to seek new prognostic indicators like red cell distribution width (RDW), which reflects the size variability of red blood cells.
- A study found that a higher RDW (over 17.35%) at diagnosis significantly correlates with worse survival rates, suggesting RDW could be an affordable and insightful biomarker for predicting outcomes in JMML patients.*
Article Abstract
Juvenile myelomonocytic leukemia (JMML) is a disorder characterized by the simultaneous presence of myeloproliferative and myelodysplastic features, primarily affecting infants and young children. Due to the heterogeneous genetic background among patients, the current clinical and laboratory prognostic features are insufficient for accurately predicting outcomes. Thus, there is a pressing need to identify novel prognostic indicators. Red cell distribution width (RDW) is a critical parameter reflecting the variability in erythrocyte size. Recent studies have emphasized that elevated RDW serves as a valuable predictive marker for unfavorable outcomes across various diseases. However, the prognostic role of RDW in JMML remains unclear. Patients with JMML from our single-center cohort between January 2008 and December 2019 were included. Overall, 77 patients were eligible. Multivariate Cox proportional hazard models showed that patients with red cell distribution width coefficient of variation (RDW-CV) >17.35% at diagnosis were susceptible to much worse overall survival rate (hazard ratio [HR] = 5.22, confidence interval [CI] = 1.50-18.21, = .010). Besides, the combination of RDW elevation and protein phosphatase non-receptor type 11 (PTPN11) mutation was likely to predict a subgroup with the worst outcomes in our cohort. RDW is an independent prognostic variable in JMML subjects. RDW may be regarded as an inexpensive biomarker to predict the clinical outcome in patients with JMML.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11049728 | PMC |
| http://dx.doi.org/10.1097/BS9.0000000000000186 | DOI Listing |
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