AI Article Synopsis

  • The study aimed to examine the spatial relationship between primary and recurrent prostate tumors after patients underwent external-beam radiation therapy using PSMA-targeted PET/CT scans.
  • Researchers analyzed data from a previous trial focusing on recurrent prostate cancer detected through PET/CT and divided the prostate into 14 sections to assess overlap between tumors.
  • Results showed that 25% of recurrent tumors were found at the same site as the primary tumor, while 41.7% had partial overlap, suggesting that recurrent tumors often arise near the original tumor location.

Article Abstract

Purpose: We retrospectively investigated spatial pattern associations between primary and recurrent tumor sites after definitive external-beam radiation therapy (EBRT) for prostate cancer, using positron emission tomography/computed tomography (PET/CT) with a prostate-specific membrane antigen (PSMA)-targeted probe, F-FSU-880.

Methods And Materials: We used data from our prior phase 2 trial involving patients who received PET/CT with F-FSU-880, which was designed to evaluate the tumor detection efficacy of PSMA-PET/CT for recurrent prostate cancer. Data from patients with local intraprostatic recurrence detected by PSMA-PET/CT after definitive EBRT were retrospectively analyzed. The prostate and seminal vesicles were divided into 14 sections. Two diagnostic radiologists separately re-evaluated the intraprostatic location of the primary tumor on magnetic-resonance imaging and that of the recurrent tumor on PSMA-PET/CT, respectively, and the rate of overlap between primary and recurrent tumors was calculated. The overlap rate was defined as "the number of sections that overlapped between the primary tumor and recurrent tumor" divided by "the total number of sections of recurrent tumor". A recurrent tumor was considered to be at the same location as the primary tumor when the overlap rate was equal to or greater than 75%, and a partial overlap was defined as an overlap rate between 25 and 74%.

Results: Twelve patients had local recurrence detected by PSMA-PET/CT. The median time to diagnosis of local recurrence was 9.1 (range, 2.2-12.3) years after definitive EBRT. The recurrent tumor was detected at the same location in 25.0%, and a partial overlap was noted in 41.7%.

Conclusions: Local intraprostatic recurrence after definitive EBRT often occurs at the same site or at a partially overlapping site adjacent to the primary intraprostatic dominant lesion. Our results support the merit of focal dose-escalation for intraprostatic dominant lesions in definitive EBRT.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043806PMC
http://dx.doi.org/10.1016/j.adro.2024.101489DOI Listing

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