AI Article Synopsis
- The study investigates how changes in glucose metabolism in the left atrium are linked to persistent atrial fibrillation (AF) and its persistence.
- Researchers used advanced imaging techniques to evaluate glucose uptake in the left atrium of 36 patients with persistent AF before and after treatment, comparing the results with healthy individuals.
- They found that patients with persistent AF had significantly higher glucose uptake in the left atrium, which decreased after returning to normal heart rhythm, highlighting the potential impact of altered metabolism on AF development.
Article Abstract
The role of atrial metabolism alterations for initiation and atrial fibrillation (AF) persistence remains poorly understood. Therefore, we evaluated left atrial glucose metabolism by nicotinic acid derivative stimulated 18-fluorodeoxyglucose positron emission tomography in 36 patients with persistent AF undergoing catheter ablation before and 3 months after return to sinus rhythm and compared values against healthy controls. Under identical hemodynamics and metabolic conditions, and although left ventricular FDG uptake remained unchanged, patients in persistent AF presented significantly higher total left atrial and left atrial appendage uptake, which decreased significantly after return to sinus rhythm, despite improvement of passive and active atrial contractile function. These findings support a role of altered glucose metabolism and metabolic wasting underlying the pathophysiology of persistent AF.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11055205 | PMC |
| http://dx.doi.org/10.1016/j.jacbts.2023.11.001 | DOI Listing |
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