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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045156PMC
http://dx.doi.org/10.4103/jgid.jgid_193_23DOI Listing

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Article Synopsis
  • Women make up about one-third of people who inject drugs in the US and Canada, yet little is known about their health outcomes related to injection drug use complications, particularly infective endocarditis (IE).
  • This study focuses on identifying the clinical characteristics and outcomes of IE in women who inject drugs, using data from five hospitals in Canada between 2007 and 2018, comparing findings based on gender.
  • Results indicated that women with IE were younger and more likely to have right-sided infections than men, with urban women experiencing higher mortality rates; those receiving substance use counseling in inpatient settings had better survival outcomes.
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A 2-year-old boy with a hemodynamically insignificant ventricular septal defect was found to have polyvalvular endocarditis, eventually requiring replacement of the pulmonary and mitral valves with a pulmonary conduit and a mechanical valve. Cultures grew , listed on the microbiological criterion of the updated Duke International Society for Cardiovascular Infectious Diseases criteria.

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Article Synopsis
  • Information on infective endocarditis (IE) caused by Cutibacterium spp. is scarce, and the effectiveness of new Duke-ISCVID criteria for diagnosis is still under study.
  • A national study from 2008 to 2023 found that 1% of IE cases were caused by Cutibacterium, predominantly in men, leading to serious intracardiac complications and significant mortality rates.
  • The new diagnostic criteria and molecular testing show promise for identifying Cutibacterium IE, highlighting the importance of cardiac surgery and device removal in reducing patient mortality.
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Recent Insights Into Native Valve Infective Endocarditis: JACC Focus Seminar 4/4.

J Am Coll Cardiol

April 2024

Department of Medicine and Department of Cardiovascular Medicine, Division of Public Health, Infectious Diseases and Occupational Health, Mayo Clinic, Rochester, Minnesota, USA.

This focused review highlights the latest issues in native valve infective endocarditis. Native valve disease moderately increases the risk of developing infective endocarditis. In 2023, new diagnostic criteria were published by the Duke-International Society of Cardiovascular Infectious Diseases group.

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