: Gastric cancer is an invasive cancer, which is usually diagnosed in advanced stages. However, the markers affecting its progression, and invasion are of great importance in its diagnosis and treatment. The current research aimed to study the correlation of genes that contributed to epithelial-mesenchymal transition (EMT), and , with some clinicopathological specifications in gastric cancer patients to better comprehend the functions of these genes in this tumor. : RNA was extracted from the tumor, and normal tissues and cDNA were synthesized. Then, by designing specific primers for and genes, their expressions were studied by RT-PCR. The data was analyzed by GraphPad Prism 8 software. Significant differences among the expressions of mentioned genes associated with clinicopathological variables of gastric cancer patients, including tumor size, grade, stage, metastasis, and lymphatic invasion were seen. : The obtained data showed the important role of EMT-related genes, and in the clinical progression of the tumor. Further studies with larger sample sizes are required to confirm these genes as biomarker candidates for detecting gastric cancer.
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| http://dx.doi.org/10.18502/ijhoscr.v18i1.14747 | DOI Listing |
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