AI Article Synopsis
- A study was conducted to compare the effectiveness of two types of spacers, hyaluronic acid (HA) and hydrogel spacer (HS), in reducing rectal toxicity during prostate cancer radiotherapy.
- The study involved 38 patients, with HS and HA impacting different doses of radiation to the rectum, demonstrating that HA provided a significantly lower dose compared to HS.
- The findings suggest that HA not only reduces rectal radiation exposure more effectively but also has better spatial expansion capabilities, indicating its potential as a preferred option over HS.
Article Abstract
Objectives: Hydrogel spacer (HS) was developed to reduce rectal toxicities caused by radiotherapy, but has been reported to cause major adverse events. Our institute has attempted to introduce a hyaluronic acid (HA) as an alternative spacer. This study aimed to compare rectal doses and geometric distributions between the HS and HA implantation in prostate cancer.
Methods: HS and HA were inserted in 20 and 18 patients undergoing high-dose brachytherapy, respectively. The rectum spacer volumes injected were 10 mL and 22 mL, respectively. In the treatment planning system, 13.5 Gy was administered with common catheter positions. The rectal dose indices were assessed between the spacer groups for dosimetry evaluation. Distances between the prostate and rectum and configurations of the spacers were compared.
Results: The mean doses irradiated to 0.1 and 2 mL of the rectum were 10.45 Gy and 6.71 Gy for HS, and 6.73 Gy and 4.90 Gy for HA (<0.001). The mean minimum distances between the prostate and rectum were 1.23 cm and 1.79 cm for HS and HA, respectively (<0.05). Geometrical configuration comparisons revealed that HA has a higher ability to expand the space than HS.
Conclusion: The rectal dose reduction ability of HA is significantly greater than that of HS, suggesting its potential as a new spacer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11053323 | PMC |
| http://dx.doi.org/10.1016/j.ajur.2022.08.006 | DOI Listing |
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