The class of doubly robust (DR) functionals studied by Rotnitzky et al. (2021) is of central importance in economics and biostatistics. It strictly includes both (i) the class of mean-square continuous functionals that can be written as an expectation of an affine functional of a conditional expectation studied by Chernozhukov et al. (2022b) and the class of functionals studied by Robins et al. (2008). The present state-of-the-art estimators for DR functionals are double-machine-learning (DML) estimators (Chernozhukov et al., 2018). A DML estimator of depends on estimates and of a pair of nuisance functions and , and is said to satisfy "rate double-robustness" if the Cauchy-Schwarz upper bound of its bias is . Were it achievable, our scientific goal would have been to construct valid, assumption-lean (i.e. no complexity-reducing assumptions on or ) tests of the validity of a nominal () Wald confidence interval (CI) centered at . But this would require a test of the bias to be , which can be shown not to exist. We therefore adopt the less ambitious goal of falsifying, when possible, an analyst's justification for her claim that the reported () Wald CI is valid. In many instances, an analyst justifies her claim by imposing complexity-reducing assumptions on and to ensure "rate double-robustness". Here we exhibit valid, assumption-lean tests of : "rate double-robustness holds", with non-trivial power against certain alternatives. If is rejected, we will have falsified her justification. However, no assumption-lean test of , including ours, can be a consistent test. Thus, the failure of our test to reject is not meaningful evidence in favor of .
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http://dx.doi.org/10.1016/j.jeconom.2023.105500 | DOI Listing |
Inorg Chem
January 2025
Department of Chemistry University of Tennessee, Knoxville, Tennessee 37996-1600, United States.
A series of 2-pyridone[α]-fused BOPHYs - were prepared via a two-step procedure involving the preparation of enamine, followed by an intramolecular heterocyclization reaction. In addition to being fully conjugated with the BOPHY core pyridone fragment, BOPHYs and have a pyridine group connected to the BOPHY core via one- or two -CH- groups. New BOPHYs were characterized by spectroscopy as well as X-ray diffraction.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Physics, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
In this research, the effect of seed halopriming with plasma activated water (PAW) on wheat germination parameters have been studied. Response surface methodology was used to investigate the effect of three factors including: 1) type of water (distilled water, 0.2 and 0.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Background: Cinnamon has been studied as a possible way to control blood glucose and serum cholesterol levels. However, there are no well-conducted randomized controlled trials that can accurately measure the lipid and glucose-lowering effects of Cinnamomum zeylanicum (C. zeylanicum) extract.
View Article and Find Full Text PDFSci Adv
January 2025
Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Understanding chromatin organization requires integrating measurements of genome connectivity and physical structure. It is well established that cohesin is essential for TAD and loop connectivity features in Hi-C, but the corresponding change in physical structure has not been studied using electron microscopy. Pairing chromatin scanning transmission electron tomography with multiomic analysis and single-molecule localization microscopy, we study the role of cohesin in regulating the conformationally defined chromatin nanoscopic packing domains.
View Article and Find Full Text PDFPLoS One
January 2025
China Football Academy, Beijing Sport University, Beijing, China.
Background: The match physical demands placed on soccer referees are intrinsically connected to their capacity to make accurate judgments, becoming the second most studied theme in associate soccer refereeing.
Objective: This study aims to review the external and internal load performed by soccer referees in high-level competitions, to identify changes in these indicators over different periods as the competition progresses, and to analyze the standards for dividing speed zones and heart rate zones.
Methods: Web of Science, PubMed, Scopus, and EBSCOhost were thoroughly searched.
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