35 cases of non-Hodgkin malignant lymphomas of head and neck, stages I and II. All were treated in Pitié-Salpêtrière Hospital in Paris, by radiotherapy alone or combination chemotherapy and radiotherapy, with or without surgery. The authors discuss the prognostic and therapeutic aspects.
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Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets.
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Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138 cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic from polyclonal/normal PCs and find more dysregulated genes, especially in precursor patients, than we would have by analyzing bulk PCs. To determine whether this approach can identify oncogenes that contribute to disease pathobiology, mitotic arrest deficient-2 like-1 (MAD2L1) and S-adenosylmethionine synthase isoform type-2 (MAT2A) are validated as targets with drug-like molecules that suppress myeloma growth in preclinical models.
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