AI Article Synopsis
- Prostate-specific membrane antigen (PSMA) PET significantly enhances management decisions for patients with biochemically recurrent prostate cancer by revealing more positive findings compared to MRI and CT alone.
- The study analyzed data from 41 patients, showing that the combination of PET with either MRI or CT led to improved detection rates and altered treatment plans for a considerable number of patients.
- The interreader agreement improved significantly with the addition of PET, highlighting its importance in clinical assessment and decision-making.
Article Abstract
Background: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) can change management in a large fraction of patients with biochemically recurrent prostate cancer (BCR).
Purpose: To investigate the added value of PET to MRI and CT for this patient group, and to explore whether the choice of the PET paired modality (PET/MRI vs. PET/CT) impacts detection rates and clinical management.
Study Type: Retrospective.
Subjects: 41 patients with BCR (median age [range]: 68 [55-78]).
Field Strength/sequence: 3T, including T1-weighted gradient echo (GRE), T2-weighted turbo spin echo (TSE) and dynamic contrast-enhanced GRE sequences, diffusion-weighted echo-planar imaging, and a T1-weighted TSE spine sequence. In addition to MRI, [F]PSMA-1007 PET and low-dose CT were acquired on the same day.
Assessment: Images were reported using a five-point Likert scale by two teams each consisting of a radiologist and a nuclear medicine physician. The radiologist performed a reading using CT and MRI data and a joint reading between radiologist and nuclear medicine physician was performed using MRI, CT, and PET from either PET/MRI or PET/CT. Findings were presented to an oncologist to create intended treatment plans. Intrareader and interreader agreement analysis was performed.
Statistical Tests: McNemar test, Cohen's κ, and intraclass correlation coefficients. A P-value <0.05 was considered significant.
Results: 7 patients had positive findings on MRI and CT, 22 patients on joint reading with PET/CT, and 18 patients joint reading with PET/MRI. For overall positivity, interreader agreement was poor for MR and CT (κ = 0.36) and almost perfect with addition of PET (PET/CT κ = 0.85, PET/MRI κ = 0.85). The addition of PET from PET/CT and PET/MRI changed intended treatment in 20 and 18 patients, respectively. Between joint readings, intended treatment was different for eight patients.
Data Conclusion: The addition of [F]PSMA-1007 PET/MRI or PET/CT to MRI and CT may increase detection rates, could reduce interreader variability, and may change intended treatment in half of patients with BCR.
Level Of Evidence: 3 TECHNICAL EFFICACY: Stage 3.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645485 | PMC |
| http://dx.doi.org/10.1002/jmri.29386 | DOI Listing |
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