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Acute pancreatitis in intraductal papillary mucinous neoplasm: Associations with epithelial subtype, degree of dysplasia, and risk of recurrence.
Surgery
December 2024
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:
Article Synopsis
- Acute pancreatitis is a significant indicator in patients with intraductal papillary mucinous neoplasms (IPMNs), as about 19.2% of patients showed this symptom, often leading to diagnosis.
- Acute pancreatitis is linked to a higher risk of high-grade dysplasia (2.07 times more likely) and certain types of IPMNs, but it is less associated with invasive cancer (0.62 times less likely).
- After surgical resection, 9% of patients with a history of pancreatitis experienced recurrent episodes, compared to only 0.9% in those without prior pancreatitis.
Outcomes of pancreatectomy for histologically proven intraductal papillary mucinous neoplasm with reference to Fukuoka guidelines.
ANZ J Surg
December 2024
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong.
Background: Intraductal papillary mucinous tumour (IPMN) of pancreas is increasingly recognized to have malignant potential. Fukuoka guidelines are commonly used to select patients with IPMN for resection due to high chance of malignancy, which includes high-grade dysplasia (HGD) or invasive carcinoma (IC).
Methods: A retrospective study on consecutive patients who have undergone pancreatectomy with IPMN as the final pathology was performed.
Histological Subtypes Might Help Risk Stratification in Different Morphological Types of IPMNs: Back to the Future?
J Clin Med
November 2024
Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, 141 52 Stockholm, Sweden.
Intraductal papillary mucinous neoplasms (IPMNs) display four histological subtypes: gastric foveolar, pancreaticobiliary, intestinal, and oncocytic. All of these subtypes harbor a different risk of cancer development. The clinical impact of these subtypes concerning the occurrence of high-grade dysplasia (HGD)/cancer (C) in specific morphological types, such as branch-duct (BD), main-duct (MD), and mixed-type (MT) IPMNs, has been less investigated.
View Article and Find Full Text PDFPerformance of high-resolution diffusion-weighted magnetic resonance imaging for detecting clinically occult early breast cancers: a multi-reader study.
Breast Cancer Res Treat
November 2024
Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Purpose: To compare mammography, breast ultrasound (US), high-resolution diffusion-weighted magnetic resonance imaging (DW-MRI), dynamic contrast-enhanced breast MRI (DCE-MRI), and their combinations for detecting clinically occult early breast cancers (EBCs), including ductal carcinoma in situ (DCIS).
Methods: Three hundred and three consecutive women with screening imaging-detected early breast cancers (60 pure DCIS, 36 DCIS with microinvasion, and 207 invasive carcinoma less than 20 mm) who underwent breast MRI at 3 T including DW-MRI (b-values of 0, 800 and 1200 s/mm; in-plane resolution, 1.1 × 1.
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