AI Article Synopsis
- The study investigates the effects of female chromosomal polymorphisms (FCPs) on the outcomes of IVF and ICSI, finding inconsistent results in past research.
- In a cohort of 951 couples with FCPs and 10,788 with normal karyotypes, results showed that FCPs significantly reduced oocyte maturation rates, particularly with rare FCPs, but had little impact on other IVF/ICSI results.
- The study also noted that specific FCPs like female qh+ correlated with higher success rates in IVF but lower normal fertilization rates in ICSI, and an increased risk of preterm births was associated with certain FCPs during both treatments.
Article Abstract
Background: The effects of female chromosomal polymorphisms (FCPs) on various aspects of reproductive health have been investigated, yet the findings are frequently inconsistent. This study aims to clarify the role of FCPs on the outcomes of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
Methods: This retrospective cohort study comprised 951 couples with FCPs and 10,788 couples with normal karyotypes who underwent IVF/ICSI treatment at Peking University Third Hospital between 2015 and 2021. The exposure was FCPs. The embryological outcomes and clinical outcomes were compared.
Results: The FCPs, as a whole, compromised the oocyte maturation rate (76.0% vs. 78.8%, P = 0.008), while they did not adversely affect other IVF/ICSI outcomes. Further detailed analyses showed that every type of FCPs contributed to the lower oocyte maturation rate, particularly the rare FCPs (69.0% vs. 78.8%, P = 0.008). The female qh + was associated with a higher normal fertilization rate (63.0% vs. 59.2%, adjusted P = 0.022), a higher clinical pregnancy rate (37.0% vs. 30.7%, adjusted P = 0.048), and a higher live birth rate (27.0% vs.19.0%, adjusted P = 0.003) in couples undergoing IVF. Conversely, in couples undergoing ICSI, female qh + was found to be related to a lower normal fertilization rate (58.8% vs. 63.8%, P = 0.032), a comparable clinical pregnancy rate (25.7% vs. 30.9%, P = 0.289), and a comparable live birth rate (19.8% vs. 19.2%, P = 0.880) compared to the control group. Additionally, an increased risk of preterm birth was observed in women undergoing IVF with multiple polymorphisms (62.5% vs. 16.9%, adjusted P < 0.001) and in women undergoing ICSI with pstk+ (36.4% vs. 15.4%, P = 0.036).
Conclusions: Our research unravels the diverse impacts of various FCPs on IVF/ICSI outcomes, highlighting the detrimental effects of FCPs on oocyte maturation and the risk of preterm birth.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11055351 | PMC |
| http://dx.doi.org/10.1186/s12884-024-06532-w | DOI Listing |
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