AI Article Synopsis
- - This study aimed to compare the effectiveness of two vitamin K prophylactic regimens on PIVKA-II and PT-INR levels in healthy newborns.
- - A total of 119 infants were either given vitamin K three times (at birth, 5 days, and 1 month) or thirteen times (at the same times plus weekly for 11 weeks).
- - Results showed that the 13-time regimen significantly improved coagulation markers in both breastfed and formula-fed infants, while the 3-time regimen had limited effects.
Article Abstract
Objective: This prospective study compared PIVKA-II and PT-INR levels in infants who received two vitamin K (VK) prophylactic regimens.
Methods: A single institution administered 119 healthy newborns 2 mg of VK syrup. Infants were assigned to a 3-time regimen (n = 56) with VK at birth, five days (5D), and 1-month-old (1 M), or a 13-time regimen (n = 63) with VK at birth, 5D, and then weekly for 11 weeks.
Results: The 13-time regimen significantly lowered PIVKA-II and reduced PT-INR at 1 M in both breastfed (PIVKA-II: 18-16 mAU/mL, p = 0.02; PT-INR: 1.37-1.13, p < 0.01) and formula-fed infants (PIVKA-II: 18-15 mAU/mL, p = 0.01; PT-INR: 1.54-1.24, p < 0.01), compared to baseline measurements taken at 5D. The 3-time regimen did not significantly alter PIVKA-II levels and only improved PT-INR (2.00-1.50, p < 0.01) in formula-fed infants.
Conclusion: The 13-time VK regimen significantly enhanced coagulation profiles more effectively than the 3-time regimen.
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| http://dx.doi.org/10.1038/s41372-024-01981-9 | DOI Listing |
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