AI Article Synopsis
- - The study explored the effectiveness of contrast enhancement ultrasound (CEUS) as a non-invasive method for identifying sentinel lymph nodes (SLNs) in early breast cancer patients, comparing it to the traditional sentinel lymph node biopsy (SLNB) technique.
- - Conducted as part of a larger phase 3 study, the research involved patients undergoing surgery for early breast cancer, where CEUS helped locate and mark lymph nodes for later analysis, with a focus on identifying any cancerous cells present.
- - Results showed that CEUS successfully identified and marked lymph nodes in most patients, with a significant portion demonstrating pathological findings, indicating its potential as a safe alternative for assessing axillary disease burden in early breast cancer cases.
Article Abstract
Background/aim: In the context of surgical de-escalation in early breast cancer (EBC), this study aimed to evaluate the contrast enhancement ultrasound (CEUS) sentinel lymph node (SLN) procedure as a non-invasive axillary staging procedure in EBC in comparison with standard SLN biopsy (SLNB).
Patients And Methods: A subanalysis of the AX-CES study, a prospective single-arm, monocentric phase 3 study was performed (EudraCT: 2020-000393-20). The study included patients with EBC undergoing upfront surgery and SLN resection, with no prior history of locoregional treatment, and weighing between 40-85 kg. All patients underwent the CEUS SLN procedure as a non-invasive axillary staging procedure, with CEUS SLN accumulation marked using blue dye. After the CEUS SLN procedure, all patients underwent the standard mapping procedure. Data on success rate, systemic reactions, mean procedure time, mean surgical procedure, mean procedure without axillary staging, CEUS SLN appearance (normal/pathological), SLN number, and concordance with standard mapping procedure were collected.
Results: After the CEUS SLN procedure, 29 LNs among 16 patients were identified and marked. In all cases, CEUS SLN revealed at least one LN enhancement. Six (37.50%) LNs were defined as pathological after the CEUS SLN procedure. Definitive staining of CEUS SLN pathology revealed metastatic involvement in four (66.67%) of the cases. Two SLNs were identified during the CEUS SLN procedure; however, owing to the low disease burden, no change in the surgical plan was reported.
Conclusion: The CEUS SLN procedure shows promise as a technique for non-invasive assessment of the axilla, potentially enabling safe axillary de-escalation in EBC by estimating the axillary disease burden.
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| http://dx.doi.org/10.21873/anticanres.17005 | DOI Listing |
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Article Synopsis
- - The study explored the effectiveness of contrast enhancement ultrasound (CEUS) as a non-invasive method for identifying sentinel lymph nodes (SLNs) in early breast cancer patients, comparing it to the traditional sentinel lymph node biopsy (SLNB) technique.
- - Conducted as part of a larger phase 3 study, the research involved patients undergoing surgery for early breast cancer, where CEUS helped locate and mark lymph nodes for later analysis, with a focus on identifying any cancerous cells present.
- - Results showed that CEUS successfully identified and marked lymph nodes in most patients, with a significant portion demonstrating pathological findings, indicating its potential as a safe alternative for assessing axillary disease burden in early breast cancer cases.
The Use of Sentinel Lymph Node Mapping for Canine Mast Cell Tumors.
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View Article and Find Full Text PDFMultimodal ultrasound imaging: a method to improve the accuracy of sentinel lymph node diagnosis in breast cancer.
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