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Evaluation of Individual Cardiovascular Risk in Pre-Dialysis CKD Patients by Using the Ratio of Calcium-Phosphorus Product to Estimated Glomerular Filtration Rate (Ca × P/eGFR).
Biomedicines
January 2025
Hemodialysis Unit, St. Marina Hospital, 5800 Pleven, Bulgaria.
Background: Chronic kidney disease (CKD) patients have an increased risk of cardiovascular disease (CVD), necessitating effective risk assessment methods. This study evaluates the calcium-phosphorus product (Ca × P) to estimated glomerular filtration rate (Ca × P/eGFR) ratio as a potential biomarker for predicting CV risk in pre-dialysis CKD patients.
Methods: Eighty-four CKD patients in stages G1-G4, according to the KDIGO criteria, were classified into CVD ( = 43) and non-CVD ( = 41) groups.
Switching from acetate to citrate dialysate in a central concentrate delivery system for high-volume online hemodiafiltration: a retrospective cohort study.
Ren Fail
December 2024
Division of Nephrology, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Article Synopsis
- Interest in citrate-based dialysate (Cit-D) is increasing due to its advantages in anticoagulation and dialysis efficiency, yet research on its use in high-volume hemodiafiltration (HDF) is limited.
- This study analyzed 28 patients who switched from acetate-based dialysate (Acet-D) to Cit-D, examining safety and effectiveness across three 12-week periods.
- Results showed a 17% reduction in heparin dosage, improvements in dialysis efficiency (increased Kt/V and urea reduction ratio), and no significant safety concerns, suggesting Cit-D may have benefits over Acet-D in this setting.
Calciphylaxis, beware the ophthalmic mimic: A case series.
Clin Nephrol Case Stud
December 2023
Department of Ophthalmology, and.
Article Synopsis
- This text discusses two rare cases of calciphylaxis that showed eye-related issues without typical skin symptoms, aiming to increase awareness of the condition.
- The cases include a 76-year-old woman with kidney failure and anterior ischemic optic neuropathy (AION), and a 44-year-old man on dialysis with AION and central retinal artery occlusion (CRAO).
- It emphasizes the importance of recognizing calciphylaxis in kidney patients with eye problems, and suggests a temporal artery biopsy for accurate diagnosis to prevent unnecessary treatments like steroids.
Predialysis trajectories of estimated GFR and concurrent trends of Chronic Kidney Disease-relevant biomarkers.
Ther Adv Chronic Dis
June 2023
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Background: The glomerular filtration rate (GFR) decline varies in patients with advanced chronic kidney disease (CKD), and the concurrent changes in CKD-related biomarkers are unclear.
Objectives: This study aimed to examine the changes in CKD-related biomarkers along with the kidney function decline in various GFR trajectory groups.
Design: This study was a longitudinal cohort study originated from the pre-end-stage renal disease (pre-ESRD) care program in a single tertiary center between 2006 and 2019.
High prevalence of sarcopenia and myosteatosis in patients undergoing hemodialysis.
Front Endocrinol (Lausanne)
April 2023
Department of Nephrology, Beijing Jishuitan Hospital, Beijing, China.
Background And Purpose: Sarcopenia is highly prevalent (28.5-40.3%) in patients undergoing hemodialysis and leads to poor clinical outcomes.
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