AI Article Synopsis
- The study aimed to explore the relationship between the CTSG N125S genetic polymorphism and the development of basal cell carcinoma (BCC), given that CTSG has been linked to other types of cancer and diseases.* -
- Researchers analyzed DNA samples from 98 BCC patients and 99 control subjects of Greek origin using PCR amplification techniques to genotype the CTSG N125S polymorphism.* -
- The findings indicated no significant differences in the genetic profiles between BCC patients and controls, concluding that the CTSG N125S polymorphism does not play a role in the development of BCC.*
Article Abstract
Background/aim: Cathepsin G (CTSG) has been identified as an inhibitor of breast, bladder, and colorectal cancers. The G allele of the N125S (A/G, rs45567233) functional polymorphism of the CTSG gene confers increased serum CTSG activity and has been associated with cardiovascular and neurovascular diseases. This study examined the possible correlation between the pathogenesis of basal cell carcinoma (BCC) and the functional polymorphism CTSG N125S.
Patients And Methods: A total of 197 DNA samples were examined, comprising 98 BCC patients and 99 control samples of Greek origin. The CTSG N125S polymorphism was molecularly genotyped using PCR amplification, followed by enzyme digestion, and agarose gel electrophoresis of the amplified DNA fragments.
Results: There was no statistically significant difference in the genotypic and allelic frequencies between the patient and the control groups.
Conclusion: There is no association between the CTSG N125S polymorphism and pathogenesis of BCC.
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| http://dx.doi.org/10.21873/anticanres.17013 | DOI Listing |
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