AI Article Synopsis
- The anterior pituitary produces hormones essential for reproduction, particularly FSH and LH, by cells known as gonadotrophs.
- A study on highly prolific Hu sheep revealed that the gene PPP2R2A, linked to reproductive function, is more highly expressed in sheep with greater reproductive success.
- PPP2R2A promotes the growth and hormone secretion of pituitary cells while preventing cell death, potentially through the AKT/mTOR signaling pathway, indicating its importance in regulating pituitary function and gonadotropin secretion.
Article Abstract
The anterior pituitary plays a critical role in the endocrine system, contains gonadotrophs, which regulate reproductive efficiency by secreting follicle-stimulating hormone (FSH) and luteinizing hormone (LH). PPP2R2A is a serine-threonine phosphatase that regulates reproductive functions in both females and males, its function in pituitary cells remain unclear. Hu sheep is a highly prolific breed, which makes it suitable for studying reproductive mechanisms. In this study, the relative abundances of PPP2R2A mRNA expression were higher in the pituitary of high-prolificacy (HF) Hu sheep compared to those of low-prolificacy (LF) Hu sheep. Additionally, we demonstrated that PPP2R2A promotes pituitary cell proliferation and gonadotropin secretion using the EdU assay and ELISA, respectively. Moreover, it inhibits pituitary cell apoptosis using flow cytometry. Furthermore, PPP2R2A may affect pituitary cell function by regulating the AKT/mTOR signaling pathway. In summary, our findings suggest that PPP2R2A may play a role in regulating pituitary function and influencing the secretion of gonadotropins.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.anireprosci.2024.107457 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Increased plugging latency in cycling epiERα-/- (Esr1f/-Wnt7aCre/+) mice.
Reproduction
January 2025
X Ye, Department of Physiology and Pharmacology, University of Georgia, Athens, United States.
Wnt7a-Cre is a commonly used for generating uterine epithelial conditional knockout mice, such as epiERα-/- (Esr1f/-Wnt7aCre/+) and epiPR-/- (Pgrf/-Wnt7aCre/+). We noticed that epiERα-/- females, but not epiPR-/- females, have prolonged plugging latency, which is the duration between continuous cohabitation and detection of the first vaginal plug (a sign of mating). Mating occurs in proestrus and/or estrus stages of the estrous cycle.
View Article and Find Full Text PDFMultiple microcysts and clivus invasion diagnose T-box pituitary transcription factor 19 lineage adenomas in non-functioning pituitary adenomas.
Acta Radiol
January 2025
Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
Background: Preoperative identification of T-box pituitary transcription factor 19 (TPIT) lineage silent adenomas in non-functioning pituitary adenomas (NFPAs) is important.
Purpose: To compare the clinical, laboratory, and radiological features of the three cell lineages of adenomas in NFPAs and evaluate the diagnostic efficacy of multiple microcysts and clivus invasion on magnetic resonance imaging (MRI) for TPIT lineage adenomas in NFPAs.
Material And Methods: A total of 405 patients with NFPA were retrospectively enrolled, including steroidogenic factor 1 (SF-1) lineage adenomas (n = 204), TPIT lineage adenomas (n = 111), and pituitary transcription factor 1 (PIT-1) lineage adenomas (n = 90).
Historical Control Data of Spontaneous Lesions of Laboratory New Zealand White and Dutch Belted Rabbits () Used in Toxicity Studies.
Toxicol Pathol
January 2025
Charles River Laboratories Edinburgh Ltd, Elphinstone Research Centre, Tranent, UK.
A retrospective study was performed to determine the incidences of spontaneous findings in control laboratory New Zealand White (NZW) and Dutch Belted (DB) rabbits. Terminal body and organ weights data were also collected. A total of 2170 NZW (526 males/1644 females), 100 DB rabbits (50 animals per sex), aged 4- to 7-month-old were obtained from 158 non-clinical studies evaluated between 2013 and 2022.
View Article and Find Full Text PDFSingle-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors.
J Exp Clin Cancer Res
January 2025
Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China.
Background: Bone-invasive Pituitary Neuroendocrine Tumors (BI PitNETs) epitomize an aggressive subtype of pituitary tumors characterized by bone invasion, culminating in extensive skull base bone destruction and fragmentation. This infiltration poses a significant surgical risk due to potential damage to vital nerves and arteries. However, the mechanisms underlying bone invasion caused by PitNETs remain elusive, and effective interventions for PitNET-induced bone invasion are lacking in clinical practice.
View Article and Find Full Text PDFStress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol.
Psychoneuroendocrinology
January 2025
Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium. Electronic address:
Telomere length (TL) is considered a biomarker of aging, and short TL in leukocytes is related to age and stress-related health problems. Cumulative lifetime stress exposure has also been associated with shorter TL and age-related health problems, but the mechanisms are not well understood. We tested in 108 individuals whether shorter TL in leukocytes is observed in individuals with the GABRA6 TT genotype, which has been associated with dysregulation of hypothalamic-pituitary-adrenal axis activity (the main biological stress system) compared to the CC genotype.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!