AI Article Synopsis
- Isoproterenol (ISO) causes major biochemical and tissue changes in the heart, resulting in oxidative stress and inflammation that worsen heart injury.
- Administering ISO to rats mimics aspects of human heart disease, helping researchers understand disease mechanisms and test new treatments.
- The chapter discusses how varying dosages and methods of ISO injection can be used to create different levels of heart injury for experimental purposes.
Article Abstract
Isoproterenol (ISO) administration produces significant biochemical and histological changes including oxidative stress, reactive oxygen species (ROS) overproduction, and inflammation that leads to aggravation of myocardial injury. Subcutaneous or intraperitoneal ISO injection into rats can replicate several features of human heart disease, making it a useful tool for comprehending the underlying mechanisms and evaluating potential therapeutic strategies. In the present chapter, we elaborate on how depending on the precise experimental goals and the intended level of severity, different dosages and regimens are employed to induce myocardial injury.
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| http://dx.doi.org/10.1007/978-1-0716-3846-0_9 | DOI Listing |
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