Background: Bipolar disorder (BD) is a severe mental disorder related to neurocognitive deficits. Exposure to childhood trauma is associated with worse cognitive performance. Different compositions of childhood trauma in BD and their impacts on cognition are rarely reported.
Methods: We used the Brief Assessment of Cognition in Affective Disorders (BAC-A) to assess cognitive performance and the Chinese version of the Short Form of the Childhood Trauma Questionnaire (C-CTQ-SF) to assess childhood trauma experience among 55 euthymic BD patients. Cluster analysis was applied to dissect their childhood trauma experiences, which revealed three distinct clusters: a low trauma group, neglect-focus group, and multiple-trauma-experience group. We compared the cognitive function between the three clusters and used a generalized linear model to evaluate the impact of childhood neglect on cognitive domains.
Results: The neglect-focus cluster showed prominent exposures to physical and emotional neglect (41.8%). BD patients in this cluster performed worse in BAC-A compared with patients in the multiple trauma cluster, especially in working memory and processing speed. The neglect-focus group revealed a significant negative effect on the composite score (ß = -0.904, p = 0.025) and working memory (ß = -1.150, p = 0.002) after adjusting sex, age, education year, BMI and total psychotropic defined daily dose.
Conclusions: Distinct patterns of childhood trauma experience are seen in BD patients and are related with different cognitive profiles. Early exposure of neglect-focus trauma was associated with the worst cognitive performance in current study. Further studies investigating the intensity of the neglect, as well as individual resilience and coping mechanisms in BD, are warranted.
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http://dx.doi.org/10.1186/s40345-024-00335-w | DOI Listing |
JAMA Health Forum
January 2025
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Int J Soc Psychiatry
January 2025
Department of Anthropology, University of Delhi, India.
Background: Although positive childhood experiences (PCEs) have been reported to be crucial for healthy development and better mental and physical health outcomes, their epidemiology and relationship with adverse childhood experiences (ACE) exposure in low and middle-income countries, including India remain underexplored.
Aims: The present study aimed to ascertain the prevalence and predictors of PCE exposure and understand the relationship between PCE and ACE exposure among young adults in Delhi-NCR, India.
Methods: The present cross-sectional study involved a total of 1,573 young adults (18-25 years) of both sexes (69.
J Interpers Violence
January 2025
Social and Education Sciences Department, School of Arts and Sciences, Lebanese American University, Jbeil, Lebanon.
The study objectives were to test the hypothesis that childhood trauma moderates the associations between early maladaptive schemas (EMS) and intimate partner violence (IPV) among women in the specific Lebanese patriarchal context. This is a cross-sectional study that was conducted on Lebanese women between September and December 2018; 1,655 participants enrolled in this study were from all of Lebanon's governorates and were selected using an equitable representative sample. The "Disconnection and Rejection" EMS domain showed the strongest correlations with both physical and nonphysical IPV ( = .
View Article and Find Full Text PDFJ Psychosom Res
January 2025
Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland. Electronic address:
Objective: Previous studies implied detrimental effects of adverse childhood experiences (ACE) on cardiovascular disease and mental health. Still, data on the influence of ACE on psychological distress in patients with an implantable cardioverter-defibrillator (ICD) are lacking.
Methods: We prospectively recruited 423 patients with an ICD.
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