AI Article Synopsis
- A new method for breaking C-C bonds in cycloalkanols using tetramethylammonium hypochlorite (TMAOCl) has been established.
- TMAOCl can be easily made from tetramethylammonium hydroxide, and works well with acetic acid (AcOH) in a two-phase system.
- This process successfully converts unstrained cycloalkanols into ω-chloroalkyl aryl ketones with good yields, all without the need for metals and under mild conditions.
Article Abstract
An oxidative C-C bond cleavage of -cycloalkanols with tetramethylammonium hypochlorite (TMAOCl) has been developed. TMAOCl is easy to prepare from tetramethylammonium hydroxide, and the combination of TMAOCl and AcOH effectively promoted the C-C bond cleavage in a two-phase system without additional phase-transfer reagents. Unstrained -cycloalkanols were transformed into ω-chloroalkyl aryl ketones in moderate to excellent yields under metal-free and mild reaction conditions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11055113 | PMC |
| http://dx.doi.org/10.3390/molecules29081874 | DOI Listing |
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