This paper describes the procedure of design and manufacture of a micro-ejector proposed for miniature ejection refrigeration systems. It describes the procedure of design, fabrication, and experimentation on supersonic micro-ejectors and makes the case for isobutane as a working fluid for such systems. It was demonstrated that it is possible to design and fabricate a micro-ejector with a cooling capacity of approximately 3 W. The discussed micro-ejector was driven by a heat source with temperature below 60 °C. The evaporation temperature was approximately 15 °C. For these operating parameters, the reported entrainment ratio was approximately 0.20. The difficulties in fabricating the micro-ejector due to its small dimensions are discussed in the paper. Additionally, the potential difficulties and solutions related to ensuring and maintaining stable operation of the testing stand are presented. The performance of the proposed system is demonstrated and discussed, including relations between mass entrainment ratio, compression ratio, cooling capacity, and temperature.
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http://dx.doi.org/10.3390/mi15040429 | DOI Listing |
BMC Psychiatry
January 2025
Department of Behavioural Science and Health, University College London, London, 1-19 Torrington Place, WC1E 7HB, UK.
Background: Smoking rates in the UK have declined steadily over the past decades, masking considerable inequalities, as little change has been observed among people with a mental health condition. This trial sought to assess the feasibility and acceptability of supplying an electronic cigarette (e-cigarette) starter kit for smoking cessation as an adjunct to usual care for smoking cessation, to smokers with a mental health condition treated in the community, to inform a future effectiveness trial.
Methods: This randomised controlled feasibility trial, conducted March-December 2022, compared the intervention (e-cigarette starter kit with a corresponding information leaflet and demonstration with Very Brief Advice) with a 'usual care' control at 1-month follow-up.
Nat Med
January 2025
BioNTech US, Cambridge, MA, USA.
New treatment approaches are warranted for patients with advanced melanoma refractory to immune checkpoint blockade (ICB) or BRAF-targeted therapy. We designed BNT221, a personalized, neoantigen-specific autologous T cell product derived from peripheral blood, and tested this in a 3 + 3 dose-finding study with two dose levels (DLs) in patients with locally advanced or metastatic melanoma, disease progression after ICB, measurable disease (Response Evaluation Criteria in Solid Tumors version 1.1) and, where appropriate, BRAF-targeted therapy.
View Article and Find Full Text PDFCardiovasc Eng Technol
January 2025
Transonic Systems Inc., 34 Dutch Mill Road, Ithaca, New York, 14850, USA.
Purpose: Over time, transit time flow measurement (TTFM) has proven itself as a simple and effective tool for intra-operative evaluation of coronary artery bypass grafts (CABGs). However, metrics used to screen for possible technical error show considerable spread, preventing the definition of sharp cut-off values to distinguish between patent, questionable, and failed grafts. The simulation study presented in this paper aims to quantify this uncertainty for commonly used patency metrics, and to identify the most important physiological parameters influencing it.
View Article and Find Full Text PDFCommun Med (Lond)
January 2025
International Research Center for Neurointelligence, The University of Tokyo, Tokyo, Japan.
Background: In-person interaction offers invaluable benefits to people. To guarantee safe in-person activities during a COVID-19 outbreak, effective identification of infectious individuals is essential. In this study, we aim to analyze the impact of screening with antigen tests in schools and workplaces on identifying COVID-19 infections.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Materials, University of Oxford, Parks Road, Oxford, UK.
The Selective Metallization Technique shows promise for roll-to-roll in-line patterning of flexible electronics using evaporated metals, but challenges arise when applied to sputtering functional materials. This study overcomes these challenges with simultaneous sputtering of Bi-Sb-Te and evaporation of metal (Ag or Cu) for thermoelectric layers when using Selective Metallization Technique. Large-scale manufacturing is demonstrated through roll-to-roll processing of a 0.
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