AI Article Synopsis
- - PCOS is an endocrine disorder often linked to metabolic issues in women, and Leonurine hydrochloride (Leo) is known to regulate various biological functions, but its effects on PCOS were unknown prior to this study.
- - In an experiment using a mouse model for PCOS, treatment with Leo helped to regularize menstrual cycles, normalize hormone levels (including testosterone and luteinizing hormone), and positively affected ovarian structure.
- - Transcriptome analysis revealed 177 genes associated with follicular development that were altered by Leo treatment, pointing to specific biological pathways that may explain how Leo improves hormone levels and ovarian health in PCOS.
Article Abstract
Polycystic ovary syndrome (PCOS) is an endocrine disease commonly associated with metabolic disorders in females. Leonurine hydrochloride (Leo) plays an important role in regulating immunity, tumours, uterine smooth muscle, and ovarian function. However, the effect of Leo on PCOS has not been reported. Here, we used dehydroepiandrosterone to establish a mouse model of PCOS, and some mice were then treated with Leo by gavage. We found that Leo could improve the irregular oestros cycle of PCOS mice, reverse the significantly greater serum testosterone (T) and luteinising hormone (LH) levels, significantly reduce the follicle-stimulating hormone (FSH) level, and significantly increase the LH/FSH ratio of PCOS mice. Leo could also change the phenomenon of ovaries in PCOS mice presented with cystic follicular multiplication and a lacking corpus luteum. Transcriptome analysis identified 177 differentially expressed genes related to follicular development between the model and Leo groups. Notably, the cAMP signalling pathway, neuroactive ligand-receptor interactions, the calcium signalling pathway, the ovarian steroidogenesis pathway, and the , , , , , and genes may be most related to improvements in hormone levels and the numbers of ovarian cystic follicles and corpora lutea in PCOS mice treated by Leo, which provides a reference for further study of the mechanism of Leo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050333 | PMC |
| http://dx.doi.org/10.3390/genes15040507 | DOI Listing |
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