AI Article Synopsis
- - The study explored how genetic variation and the environment affect gene expression in older adults, focusing on a community sample of 246 individuals (mostly female twins).
- - Researchers found that about 24% of the analyzed genes showed heritability in blood gene expression, with 5269 significant probes identified, particularly linked to immune response and aging.
- - Comparisons with other studies revealed that only a small fraction of heritable genes were common, underscoring the necessity of studying gene expression specifically in older populations.
Article Abstract
The contributions of genetic variation and the environment to gene expression may change across the lifespan. However, few studies have investigated the heritability of blood gene expression in older adults. The current study therefore aimed to investigate this question in a community sample of older adults. A total of 246 adults (71 MZ and 52 DZ twins, 69.91% females; mean age-75.79 ± 5.44) were studied. Peripheral blood gene expression was assessed using Illumina microarrays. A heritability analysis was performed using structural equation modelling. There were 5269 probes (19.9%) from 4603 unique genes (23.9%) (total 26,537 probes from 19,256 genes) that were significantly heritable (mean h = 0.40). A pathway analysis of the top 10% of significant genes showed enrichment for the immune response and ageing-associated genes. In a comparison with two other gene expression twin heritability studies using adults from across the lifespan, there were 38 out of 9479 overlapping genes that were significantly heritable. In conclusion, our study found ~24% of the available genes for analysis were heritable in older adults, with only a small number common across studies that used samples from across adulthood, indicating the importance of examining gene expression in older age groups.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11049887 | PMC |
| http://dx.doi.org/10.3390/genes15040495 | DOI Listing |
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