We present the case of a 35-year-old male with a first-degree family history of gastric cancer (his father was diagnosed at the age of 45), who was presumed to have gastric cancer himself when evaluating the features of his upper endoscopy performed after hematemesis. Surprisingly, no cancer cells were found in the biopsies. Thanks to a different diagnostic suspicion subsequent to performing a full clinical history, a more favorable diagnosis was reached: gastric syphilis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11052094PMC
http://dx.doi.org/10.3390/medicina60040629DOI Listing

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Article Synopsis
  • A gastroscopy revealed multiple areas of erosion with white patches from the angulus (the bend of the stomach) to the antrum (the lower portion of the stomach).
  • A gastric biopsy was taken and tested, showing numerous brown spirochetes, indicating an infection caused by syphilis.
  • The findings suggest a significant gastrointestinal issue likely linked to an underlying syphilitic infection affecting the stomach.
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Syphilitic hepatitis is a very rare presentation of syphilis infection, characterized by inflammation of the liver due to the invasion of hepatic tissue by the bacterium Treponema pallidum. This review article provides an in-depth analysis of the existing body of information pertaining to syphilitic hepatitis. The article primarily concentrates on key aspects such as the epidemiology, clinical manifestations, diagnostic methods, and therapeutic approaches associated with this condition.

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We present the case of a 35-year-old male with a first-degree family history of gastric cancer (his father was diagnosed at the age of 45), who was presumed to have gastric cancer himself when evaluating the features of his upper endoscopy performed after hematemesis. Surprisingly, no cancer cells were found in the biopsies. Thanks to a different diagnostic suspicion subsequent to performing a full clinical history, a more favorable diagnosis was reached: gastric syphilis.

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