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Novel Ultrastructural Insights into the Clear-Cell Carcinoma of the Pancreas: A Case Report. | LitMetric

AI Article Synopsis

  • * A case study of a 65-year-old male revealed tumor cells with a clear, foamy appearance, characterized by clear cytoplasmic vacuoles and a distinct lack of mucin overproduction.
  • * Advanced imaging and molecular analysis indicated that the clear-cell features in CCCP are associated with a high number of damaged mitochondria, which could influence the tumor's development and behavior.*

Article Abstract

Pancreatic cancer, most frequently as ductal adenocarcinoma (PDAC), is the third leading cause of cancer death. Clear-cell primary adenocarcinoma of the pancreas (CCCP) is a rare, aggressive, still poorly characterized subtype of PDAC. We report here a case of a 65-year-old male presenting with pancreatic neoplasia. A histochemical examination of the tumor showed large cells with clear and abundant intracytoplasmic vacuoles. The clear-cell foamy appearance was not related to the hyperproduction of mucins. Ultrastructural characterization with transmission electron microscopy revealed the massive presence of mitochondria in the clear-cell cytoplasm. The mitochondria showed disordered cristae and various degrees of loss of structural integrity. Immunohistochemistry staining for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) proved specifically negative for the clear-cell tumor. Our ultrastructural and molecular data indicate that the clear-cell nature in CCCP is linked to the accumulation of disrupted mitochondria. We propose that this may impact on the origin and progression of this PDAC subtype.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11049960PMC
http://dx.doi.org/10.3390/ijms25084313DOI Listing

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