Background: The etiopathogenesis of ACL rupture is not clarified. The aim of this study is to identify genomic regions and genetic variants relevant to anterior cruciate ligament injury susceptibility that could be involved in non-contact anterior cruciate ligament ruptures.
Methods: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines with a PRISMA checklist and algorithm. A search of PubMed, MEDLINE, CINAHL, Cochrane, EMBASE, and Google Scholar databases was conducted using combinations of the terms "anterior cruciate ligament", "ACL", "rupture", "genetics", "single nucleotide polymorphisms", and "SNP" since the inception of the databases until 2021.
Results: Twenty-three studies were included. A total of 7724 patients were analyzed. In total, 3477 patients had ACL ruptures and 4247 patients were controls. Genetic variants in genes encoding for collagens, elastin, fibrillin, matrix metalloproteinases, proteoglycans, angiogenesis-associated signaling cascade proteins, growth differentiation factors, tissue inhibitors of metalloproteases, interleukins, and fibrinogen were analyzed.
Conclusion: Findings regarding the association between genes encoding for collagen (COL3A1, COL1A1, and COL12A1), aggrecan (ACAN), decorin (DCN), matrix metalloproteinase (MMP3), interleukin 6 (IL-6), vascular endothelial growth factor A (VEGFA), biglycan (BGN), fibrinogen (FGB), and ACL injuries were found to be inconclusive. Additional evidence is required in order to establish substantial conclusions regarding the association between genetic variants and ACL rupture.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11050965 | PMC |
| http://dx.doi.org/10.3390/jcm13082330 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
T Clusters Are More Sensitive Than Mean T Change to Detect Early and Longitudinal Changes in Anterior Cruciate Ligament Reconstructed and Healthy Knees.
J Magn Reson Imaging
December 2024
Department of Radiology, Stanford University, Stanford, California, USA.
Background: Post-traumatic osteoarthritis (PTOA) often follows anterior cruciate ligament reconstruction (ACLR), leading to early cartilage degradation. Change in mean T fails to capture subject-specific spatial-temporal variations, highlighting the need for robust quantitative methods for early PTOA detection and monitoring.
Purpose/hypothesis: Develop and apply 3D T cluster analysis to ACLR and healthy knees over 2.
Patient-specific cutting guides allow 1° precision in asymmetric anterior closing-wedge osteotomy.
J Exp Orthop
January 2025
Department of Trauma and Orthopaedics, Institute for Locomotion, Sainte-Marguerite Hospital Aix-Marseille University Marseille France.
Purpose: Asymmetric anterior closing-wedge high tibial osteotomy (ACWHTO) allows correction of both excessive posterior tibial slope (PTS) and varus deformity. However, the complexity of this surgery requires a high degree of accuracy, which is less likely to be achieved with standard instrumentations. This study aimed to determine the accuracy of 3D patient-specific cutting guides (PSCGs) to provide the accurate planned correction in the frontal and sagittal planes.
View Article and Find Full Text PDFPurpose: Using a thin semitendinosus tendon as an autograft is a risk factor for poor clinical outcomes after anterior cruciate ligament reconstruction. Preoperative evaluation of the cross-sectional area of the semitendinosus tendon using magnetic resonance imaging is useful. However, studies comparing the cross-sectional area of the semitendinosus tendon on magnetic resonance imaging and the collagen fibril diameter of the semitendinosus tendon are lacking.
View Article and Find Full Text PDFPurpose: The purpose of this study was to generate knowledge about the epidemiology and risk factors for anterior cruciate ligament (ACL) injuries in handball. It was hypothesised that the incidence of ACL injuries is high and comparable to other pivoting sports like football.
Methods: This study is based on the prospective 'ACL registry in German Sports' implemented in the 2016-2017 season.
In vivo kinematic analysis of failure cases after nonanatomical anterior cruciate ligament reconstruction: a preliminary study.
Knee Surg Relat Res
December 2024
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Background: Nonanatomical anterior cruciate ligament (ACL) reconstruction occasionally induces ACL failure without an evident injury episode, necessitating revision surgery. Although the in vivo kinematics of ACL deficiency before primary ACL reconstruction are well documented, the kinematics of ACL failure after nonanatomical reconstruction remain unexplored. The aim of this study is to investigate ACL failure kinematics following nonanatomical reconstruction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!