AI Article Synopsis
- The study evaluates the effectiveness of a survival nomogram and the albumin-bilirubin (ALBI) grade in predicting survival for advanced hepatocellular carcinoma patients treated with FOLFOX4 chemotherapy.
- The survival nomogram placed patients into risk groups but did not show significant survival differentiation, while the ALBI grade effectively categorized patients and demonstrated better survival outcomes based on grade levels.
- The findings suggest that the ALBI grade may serve as a useful prognostic tool, but further research with more patients is needed to confirm the efficacy of both tools.
Article Abstract
Background: The ability of the survival nomogram developed in the EACH study and albumin-bilirubin (ALBI) grade to predict the survival of advanced hepatocellular carcinoma (HCC) patients receiving oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX4) remains unvalidated. Here, we comprehensively evaluated these prognostic tools.
Methods: The survival nomogram and ALBI grade of each patient were assessed, and the area under the receiver operating curve (AUROC) and Harrell's C-index for the risk classification model were calculated.
Results: Overall, 76 HCC patients who received FOLFOX4 between August 2017 and June 2023 were included. The survival nomogram classified patients into low-, intermediate-, and high-risk groups, with a median overall survival (OS) of 9.82, 10.64, and 3.70 months, respectively ( = 0.23). The AUROC was 0.621 and Harrell's C-index was 0.589. However, the ALBI grade categorized all patients into grade 1, 2, and 3, with a median OS of 9.82, 6.83, and 1.58 months, respectively ( = 0.00024). The AUROC was 0.663 and Harrell's C-index was 0.663.
Conclusion: The ALBI grade can be a potential prognostic tool. However, the survival nomogram does not provide clear discrimination. Therefore, FOLFOX4 should be an option for patients with ALBI grade 1 who cannot receive immunotherapy or targeted therapy. Additional prospective studies with a larger cohort are warranted to validate the survival nomogram and ALBI grade as prognostic tools.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11051573 | PMC |
| http://dx.doi.org/10.3390/jpm14040403 | DOI Listing |
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