Parkinson's disease (PD) is a neurodegenerative movement disorder associated with a loss of dopamine neurons in the substantia nigra. The diagnosis of PD is sensitive since it shows clinical features that are common with other neurodegenerative diseases. In addition, most symptoms arise at the late stage of the disease, where most dopaminergic neurons are already damaged. Several studies reported that oxidative stress is a key modulator in the development of PD. This condition occurs due to excess reactive oxygen species (ROS) production in the cellular system and the incapability of antioxidants to neutralize it. In this study, we focused on the pathology of PD by measuring serum xanthine oxidase (XO) activity, which is an enzyme that generates ROS. Interestingly, the serum XO activity of patients with PD was markedly upregulated compared to patients with other neurological diseases (ONDs) as a control. Moreover, serum XO activity in patients with PD showed a significant correlation with the disease severity based on the Hoehn and Yahr (HY) stages. The investigation of antioxidant status also revealed that serum uric acid levels were significantly lower in the severe group (HY ≥ 3) than in the ONDs group. Together, these results suggest that XO activity may contribute to the development of PD and might potentially be a biomarker for determining disease severity in patients with PD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11048637 | PMC |
| http://dx.doi.org/10.3390/biom14040490 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of Serum Uric Acid Level With Bone Mineral Density and the Risk of Osteoporosis: A Dose-Response Meta-Analysis.
Int J Rheum Dis
January 2025
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Objective: Serum uric acid (SUA) may play positive roles in diseases associated with oxidative stress, such as osteoporosis (OP). Nevertheless, the specific impact of SUA levels on both bone mineral density (BMD) and the risk of OP remains uncertain. Considering such information crucial for clinicians when making decisions about urate-lowering therapy (ULT), we sought to fill this gap by conducting dose-response meta-analyses.
View Article and Find Full Text PDFEffects and mechanisms of theabrownin from black tea in improving hyperuricemia: Evidence from animal study and clinical trial.
Int J Biol Macromol
December 2024
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Department of Endocrinology, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen 361102, China.
Article Synopsis
- Hyperuricemia (HUA) is a condition where excess uric acid builds up in the body, and Theabrownin (TB), a compound from black tea, may help improve this condition.
- TB was found to lower uric acid levels and reduce kidney damage in HUA mice by inhibiting an enzyme (xanthine oxidase) and enhancing uric acid transport in the kidneys.
- A clinical trial with HUA patients indicated that consuming TB daily for 12 weeks effectively decreased uric acid levels without negative side effects.
Article Synopsis
- This study examines the role of serum uric acid (SUA) levels in patients undergoing off-pump coronary artery bypass (OCABG) surgery, focusing on their impact on postoperative complications like acute kidney injury (AKI).
- The research involved 144 patients and found that 20% experienced AKI, with higher preoperative SUA levels significantly linked to increased risk (OR: 2.04).
- Additionally, elevated SUA levels correlated with longer hospital stays and a higher mortality rate (up to 13% in high SUA patients), indicating that SUA is a crucial predictor for postoperative outcomes.
Nonlinear association between the serum uric acid-to-creatinine ratio and all cause mortality in patients with hypertension: a ten-year cohort study using the NHANES database.
Sci Rep
December 2024
Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
The serum uric acid-to-creatinine ratio (UCR) may be a simple method for assessing xanthine oxidase overactivation, which may contribute to an increase in serum uric acid production and oxidative stress. In this study, we investigated the nonlinear association between the UCR and long-term mortality in patients with hypertension. Data were acquired from the National Health and Nutrition Examination Survey database, and a total of 11,346 patients with hypertension were included.
View Article and Find Full Text PDFAssociation between the ratio of serum uric acid to high-density lipoprotein cholesterol and liver fat content: evidence from a Chinese health examination dataset.
Sci Rep
December 2024
Department of Health Management, Chronic Health Management Laboratory, Henan Provincial People's Hospital, Zhengzhou, 450003, China.
Despite numerous studies investigating the correlation between the serum uric acid and high-density lipoprotein cholesterol ratio (UHR) and fatty liver disease, the evidence for the dose-response relationship between UHR and liver fat content (LFC) remains uncertain. This study employs quantitative computed tomography (CT) to quantify LFC and aims to investigate the correlation and dose-response relationship between UHR levels and LFC in Chinese adults. Based on the health check-up data from 2021 at Henan Provincial People's Hospital, China, the objective of this cross-sectional study was to investigate the association between UHR levels and LFC among individuals of different genders.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!