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Corinthian Currants Promote the Expression of Paraoxonase-1 and Enhance the Antioxidant Status in Serum and Brain of 5xFAD Mouse Model of Alzheimer's Disease. | LitMetric

AI Article Synopsis

  • Paraoxonase-1 (PON1) is an antioxidant enzyme linked to Alzheimer's disease (AD) that may be affected by dietary components, like Corinthian currants, known for their neuroprotective properties.* -
  • A study on 5xFAD mice found that a diet supplemented with Corinthian currant paste for 1 month increased PON1 activity and decreased oxidized lipid levels, suggesting a potential protective role against oxidative stress in AD.* -
  • The beneficial effects on PON1 activity from the currant diet were primarily seen at 1 and 3 months, linked to increased expression of PON1 in liver cells, indicating that these phenolic compounds could be significant in managing oxidative

Article Abstract

Paraoxonase-1 (PON1), a serum antioxidant enzyme, has been implicated in Alzheimer's disease (AD) pathogenesis that involves early oxidative damage. Corinthian currants and their components have been shown to display antioxidant and other neuroprotective effects in AD. We evaluated the effect of a Corinthian currant paste-supplemented diet (CurD), provided to 1-month-old 5xFAD mice for 1, 3, and 6 months, on PON1 activity and levels of oxidation markers in serum and the brain of mice as compared to a control diet (ConD) or glucose/fructose-matched diet (GFD). Administration of CurD for 1 month increased PON1 activity and decreased oxidized lipid levels in serum compared to ConD and GFD. Longer-term administration of CurD did not, however, affect serum PON1 activity and oxidized lipid levels. Furthermore, CurD administered for 1 and 3 months, but not for 6 months, increased PON1 activity and decreased free radical levels in the cortex of mice compared to ConD and GFD. To probe the mechanism for the increased PON1 activity in mice, we studied the effect of Corinthian currant polar phenolic extract on PON1 activity secreted by Huh-7 hepatocytes or HEK293 cells transfected with a PON1-expressing plasmid. Incubation of cells with the extract led to a dose-dependent increase of secreted PON1 activity, which was attributed to increased cellular PON1 expression. Collectively, our findings suggest that phenolics in Corinthian currants can increase the hepatic expression and activity of antioxidant enzyme PON1 and that a Corinthian currant-supplemented diet during the early stages of AD in mice reduces brain oxidative stress.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047902PMC
http://dx.doi.org/10.3390/biom14040426DOI Listing

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