The ATP-binding cassette (ABC) transporters are a superfamily of membrane proteins. These active transporters are involved in the export of different substances such as xenobiotics. ABC transporters from subfamily C (ABCC) have also been described as functional receptors for different insecticidal proteins from (Bt) in several lepidopteran species. Numerous studies have characterized the relationship between the ABCC2 transporter and Bt Cry1 proteins. Although other ABCC transporters sharing structural and functional similarities have been described, little is known of their role in the mode of action of Bt proteins. For , only the ABCC2 transporter and its interaction with Cry1A proteins have been studied to date. Here, we have searched for paralogs to the gene in , and identified two new ABC transporter genes: and . Furthermore, we have characterized their gene expression in the midgut and their protein topology, and compared them with that of ABCC2. Finally, we discuss their possible interaction with Bt proteins by performing protein docking analysis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047971 | PMC |
| http://dx.doi.org/10.3390/biom14040397 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inheritance of Cry2Ab2 resistance in two Helicoverpa zea (Lepidoptera: Noctuidae) populations resistant to single- and dual-Bacillus thuringiensis proteins.
J Invertebr Pathol
February 2025
Department of Entomology, Louisiana State University Agricultural Center, Baton Rouge, LA 70803, USA.
Cry2Ab2 is a Bacillus thuringiensis (Bt) protein that has been pyramided with Cry1A.105 in transgenic maize and Cry1Ac in cotton to control some major lepidopteran pests including the corn earworm/bollworm, Helicoverpa zea (Boddie). However, the widespread occurrence of resistance of this pest to the pyramided Cry1A/Cry2A crops in the southern region of the United State has become a threat to the sustainability of the technology.
View Article and Find Full Text PDFCry1 resistance in a CRISPR/Cas9-mediated HaCad1 gene knockout strain of the Australian cotton bollworm Helicoverpa armigera conferta (Lepidoptera: Noctuidae).
Pest Manag Sci
February 2025
Faculty of Science and Technology, University of Canberra, Canberra, Australia.
Background: Helicoverpa armigera is a highly polyphagous species that causes huge losses to agricultural and horticultural crops worldwide. In the cotton industry, H. armigera, including the Australian subspecies Helicoverpa armigera conferta, is largely managed using genetically modified crops that express insecticidal toxins, such as Cry1Ac.
View Article and Find Full Text PDFIncipient resistance of the African maize stemborer, Busseola fusca (Lepidoptera: Noctuidae) to Cry2Ab2 maize in South Africa.
Pest Manag Sci
November 2024
IPM Program, Unit for Environmental Science and Management, North-West University, Potchefstroom, South Africa.
Background: Resistance of Busseola fusca (Lepidoptera: Noctuidae) to Cry1Ab was documented in 2006, 7 years after the first cultivation of MON 810 in South Africa. This was mitigated by introducing a second-generation Bacillus thuringiensis (Bt) maize (MON 89034), which contains the Cry1A.105 and Cry2Ab2 proteins.
View Article and Find Full Text PDFHeat-inactivated Streptococcus pneumoniae augments circadian clock gene expression in zebrafish cells.
Sci Rep
November 2024
Department of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, USA.
The circadian clock is a cell-autonomous process that regulates daily internal rhythms by interacting with environmental signals. Reports across species show that infection can alter the expression of circadian genes; however, in teleosts, these effects are influenced by light exposure. Currently, no reports analyze the direct effects of bacterial exposure on the zebrafish clock.
View Article and Find Full Text PDFGenetic basis of resistance to Cry1Ac in Rachiplusia nu (Lepidoptera: Noctuidae): inheritance mode, cross-resistance patterns and fitness cost.
Pest Manag Sci
February 2025
Department of Plant Protection, Federal University of Santa Maria, Santa Maria, Brazil.
Article Synopsis
- - Rachiplusia nu (R. nu) has evolved from a secondary pest to a significant threat to soybean crops in Brazil and Argentina, particularly with those engineered to produce the Cry1Ac toxin, leading researchers to investigate resistance mechanisms.
- - An experiment revealed that a resistant strain of R. nu can thrive on Cry1Ac soybean leaves, showing a resistance ratio greater than 736 times, while susceptible strains quickly died off; this resistance is autosomal recessive and monogenic with minimal fitness costs.
- - The study found cross-resistance to another toxin (Cry1A.105) but not to Cry2Ab2, suggesting the combination of Cry1Ac, Cry1A.105, and Cry2Ab
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!