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Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis.
Transl Oncol
January 2025
Department of Surgery, The Second Affiliated Hospital of Jiaxing University, No. 397, Huangcheng North Road, Jiaxing, Zhejiang, 314000, China. Electronic address:
Epidermal growth factor receptor (EGFR) plays an important role in the regulation of cell proliferation and migration [1]. It forms a homodimer or heterodimer with other ErbB receptor family members to activate downstream signaling. Emerging evidence indicates that the EGFR activity and downstream signaling are regulated by other proteins except its family members during tumorigenesis.
View Article and Find Full Text PDFROMP of Macromonomers Prepared by ROMP: Expanding Access to Complex, Functional Bottlebrush Polymers.
J Am Chem Soc
January 2025
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Graft-through ring-opening metathesis polymerization (ROMP) of norbornene-terminated macromonomers (MMs) prepared using various polymerization methods has been extensively used for the synthesis of bottlebrush (co)polymers, yet the potential of ROMP for the synthesis of MMs that can subsequently be polymerized by graft-through ROMP to produce new bottlebrush compositions remains untapped. Here, we report an efficient "ROMP-of-ROMP" method that involves the synthesis of norbornene-terminated poly(norbornene imide) (PNI)-based MMs that, following ROMP, provide new families of bottlebrush (co)polymers and "brush-on-brush" hierarchical architectures. In the bulk state, the organization of the PNI pendants drives bottlebrush backbone extension to enable rapid assembly of asymmetric lamellar morphologies with large asymmetry factors.
View Article and Find Full Text PDFReaccreditation and Pathways Recognition Experiences of Small Local and Tribal Health Departments.
J Public Health Manag Pract
November 2024
Author Affiliations: Prevention Research Center, Brown School, Washington University in St. Louis, St. Louis, Missouri (Allen and Crenshaw); Department of Health Policy and Organization, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama (Fifolt); School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama (Erwin); Research and Evaluation, Public Health Accreditation Board, Alexandria, Virginia (Lang, Belflower Thomas, and Kuehnert); and Lipstein Distinguished Professor of Public Health, Prevention Research Center, Brown School, and Alvin J. Siteman Cancer Center and Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine; Washington University in St. Louis, St. Louis, Missouri (Brownson).
Context: This paper describes experiences and views of leadership teams from 4 small local health departments (LHDs) seeking Public Health Accreditation Board (PHAB) reaccreditation or Pathways Recognition using PHAB Standards & Measures Version 2022. The Pathways program launched in 2022 provides additional supports for improvement of public health practice.
Objective: Given the need to accelerate accreditation among small health departments, the purpose of this study is to share small health departments' strategies for overcoming accreditation challenges and actionable advice for use by other health departments.
A Typology of US Public Health Work-Education Programs.
J Public Health Manag Pract
November 2024
Author Affiliations: Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts (Drs White and Elliott, Ms Cunnington, and Dr Greece); Department of Medicine, Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts (Dr Drainoni); Evans Center for Implementation and Improvement Sciences, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts (Dr Drainoni); Department of Health, Law, Policy and Management, Boston University School of Public Health, Boston, Massachusetts (Dr Drainoni); and Winthrop Department of Public Health & Clinical Services, Winthrop, Massachusetts (Ms Hurley).
Objective: A pipeline is required to build a qualified and diverse public health workforce. Work-education programs offer public health students experiential learning, training, and a pathway to public health professions. However, there is a gap in the literature to guide public health practice on the types of programs, their components, and their potential impact.
View Article and Find Full Text PDFTargeted Theranostic Nanoprobes Assisted NIR-II Fluorescence Imaging-Guided Surgery Therapy for Alveolar Echinococcosis.
ACS Appl Mater Interfaces
January 2025
School of Public Health, Xinjiang Medical University, Urumqi 830054, China.
Alveolar echinococcosis (AE) is a serious parasitic infectious disease that is highly invasive and destructive to the liver and has a high mortality rate. However, currently, there is no effective targeted imaging and treatment method for the precise detection and therapy of AE. We proposed a new two-step targeting strategy (TSTS) for AE based on poly(lactic--glycolic acid) (PLGA).
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