AI Article Synopsis
- The study investigates how different cord-clamping strategies after birth affect blood pressure (BP) and cerebral tissue oxygen saturation (rStO) in infants needing resuscitation.
- Infants were randomly assigned to either a physiologically-based cord clamping (PBCC) method, where resuscitation starts before cord clamping, or early cord clamping (ECC), with both groups showing similar BP and rStO levels.
- The findings suggest that cord clamping timing doesn't significantly impact BP or rStO for infants who don't need advanced resuscitation, establishing new reference ranges for vigorous late-preterm and full-term infants undergoing deferred cord clamping.
Article Abstract
Background: Cord-clamping strategies may modify blood pressure (BP) and cerebral tissue oxygen saturation (rStO) immediately after birth.
Methods: We conducted a sub-study nested within the Baby-Directed Umbilical Cord-Clamping trial. Infants ≥32 weeks' gestation assessed as requiring resuscitation were randomly allocated to either physiologically-based cord clamping (PBCC), where resuscitation commenced prior to umbilical cord clamping, or standard care where cord clamping occurred early (ECC). In this single-site sub-study, we obtained additional measurements of pre-ductal BP and rStO. In a separate observational arm, non-randomised vigorous infants received 2 min of deferred cord clamping (DCC) and contributed data for reference percentiles.
Results: Among 161 included infants, n = 55 were randomly allocated to PBCC (n = 30) or ECC (n = 25). The mean (SD) BP at 3-4 min after birth (primary outcome) in the PBCC group was 64 (10) mmHg compared to 62 (10) mmHg in the ECC group, mean difference 2 mmHg (95% confidence interval -3-8 mmHg, p = 0.42). BP and rStO were similar across both randomised arms and the observational arm (n = 106).
Conclusion: We found no difference in BP or rStO with the different cord clamping strategies. We report reference ranges for BP and rStO for late-preterm and full-term infants receiving DCC.
Impact: Among late-preterm and full-term infants receiving varying levels of resuscitation, blood pressure (BP, at 3-4 minutes and 6 min) and cerebral tissue oxygen saturation (rStO) are not influenced by timing of cord clamping in relation to establishment of ventilation. Infants in this study did not require advanced resuscitation, where cord clamping strategies may yet influence BP and rStO. The reference ranges for BP and rStO represent the first, to our knowledge, for vigorous late-preterm and full-term infants receiving deferred cord clamping. rStO > 90% (~90 percentile) may be used to define cerebral hyperoxia, for instance when studying oxygen supplementation after birth.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257956 | PMC |
| http://dx.doi.org/10.1038/s41390-024-03131-5 | DOI Listing |
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