The highly selective and sensitive fluorescence probe for detection of copper (II) ions and its bioimaging in vitro and vivo.

Spectrochim Acta A Mol Biomol Spectrosc

College of Laboratory Medicine, Zhang Jiakou Key Laboratory of Organic Light Functional Materials, Hebei Key Laboratory of Neuropharmacology and Hebei Key Laboratory of Quality & Safety Analysis-Testing for Agro-Products and Food, Hebei North University, Zhangjiakou, 075000, Hebei Province, People's Republic of China. Electronic address:

Published: August 2024

We designed and developed the probe W-3 for detection of Cu. The results showed probe can selectively detect Cu, accompanied by noticeable color change. The probe can detect the Cu in water samples and drinks based on absorption detection. In addition, the combination of portable test paper and the smartphone platform obtained great convenience for on-site and visual detection of Cu, with satisfactory sensitivity and reliability. More importantly, the fluorescence probe W-3 can be used for the detection of Cu in cells and mice. Therefore, the W-3 provided potential chemical tools for detecting Cu in vitro and vivo.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2024.124328DOI Listing

Publication Analysis

Top Keywords

fluorescence probe
8
vitro vivo
8
probe w-3
8
w-3 detection
8
probe
5
detection
5
highly selective
4
selective sensitive
4
sensitive fluorescence
4
probe detection
4

Similar Publications

Ratiometric fluorescent probe and smartphone-based visual recognition for HO and organophosphorus pesticide based on Ce/Ce cascade enzyme reaction.

Food Chem

December 2024

Laboratory of Functional Polymers, School of Materials Science and Engineering, Linyi University, Linyi 276005, China. Electronic address:

Organicphosphorus is a ubiquitous pesticide that has potential hazards to human health and environmental well-being. Therefore, the precise identification of residues of organophosphorus pesticides (OPs) emerges as an urgent necessity. A ratiometric fluorescent sensor for the detection of OPs by leveraging the catalytic activities of Ce and Ce on the two fluorescent substrates 4-Methylumbelliferyl phosphate (4-MUP) and o-phenylenediamine (OPD) correspondingly was designed.

View Article and Find Full Text PDF

When a body is discovered at a crime or murder scene, it is crucial to examine the body and estimate its postmortem interval (PMI). Accurate estimation of PMI is vital for identifying suspects and providing clues to resolve the case. MicroRNAs (miRNAs or miRs) are small non-coding RNAs that remain relatively stable in the cell nucleus even after death-related changes occur.

View Article and Find Full Text PDF

Direct preparation of silver nanoclusters is of great significance for their applications. In this work, by selecting sodium cyanoborohydride as a weak reducing agent to control the kinetics of the reduction reaction, we successfully prepared silver nanoclusters protected by thiol-containing ligands, including mercaptosuccinic acid, cysteine, and glutathione. Based on the silver nanoclusters protected by mercaptosuccinic acid, silver-gold alloy nanoclusters were obtained through a gold doping reaction.

View Article and Find Full Text PDF

BODIPY-Based Ratiometric Fluorescent Probe for Sensing Peroxynitrite in Inflammatory Cells and Tissues.

Biosensors (Basel)

December 2024

State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.

Peroxynitrite (ONOO) plays an important role in many physiological and pathological processes. Excessive ONOO in cells leads to oxidative stress and inflammation. However, precise monitoring of ONOO levels in specific organelles (e.

View Article and Find Full Text PDF

In this study, 3,4-diaminobenzoic acid (DABA) was introduced into the porphyrin metal-organic framework (PCN-224) for the first time to prepare a ratiometric fluorescent probe (PCN-224-DABA) to quantitatively detect ferric iron (Fe(III)) and selenium (IV) (Se(IV)). The fluorescence attributed to the DABA of PCN-224-DABA at 345 nm can be selectively quenched by Fe(III) and Se(IV), but the fluorescence emission peak attributed to tetrakis (4-carboxyphenyl) porphyrin (TCPP) at 475 nm will not be disturbed. Therefore, the ratio of I/I with an excitation wavelength of 270 nm can be designed to determine Fe(III) and Se(IV).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!