AI Article Synopsis
- Cinnamon and motherwort, traditional Chinese medicines, are used together to treat benign prostatic hyperplasia, but their specific mechanisms are not well understood.
- This study utilized a network pharmacology approach to uncover how these herbs work, identifying 22 active ingredients and 130 effective targets related to key signaling pathways.
- The findings can help enhance clinical applications of this drug pair and suggest future research directions into their therapeutic mechanisms.
Article Abstract
Cinnamon and motherwort are traditional Chinese medicines and are often combined to treat benign prostatic hyperplasia; however, the specific therapeutic mechanisms involved remain unclear. Therefore, in this study, we applied a network pharmacology approach to investigate the potential mechanisms of action of the drug pair cinnamon and motherwort (PCM) for the treatment of benign prostatic hyperplasia. Relevant targets for the use of PCM to treat benign prostatic hyperplasia were obtained through databases. Protein-protein interactions were then identified by the STRING database and core targets were screened. Enrichment analysis was conducted through the Metascape platform. Finally, molecular docking experiments were carried out to evaluate the affinity between the target proteins and ligands of PCM. We identified 22 active ingredients in PCM, 315 corresponding targets and 130 effective targets of PCM for the treatment of benign prostatic hyperplasia. These targets were related to the PI3K-Akt, MAPK, FoxO, TNF, and IL-17 signaling pathways. Network pharmacology was used to identify the effective components and action targets of PCM. We also identified potential mechanisms of action for PCM in the treatment of benign prostatic hyperplasia. Our results provide a foundation for expanding the clinical application of PCM and provide new ideas and directions for further research on the mechanisms of action of PCM and its components for the treatment of benign prostatic hyperplasia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11049697 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000037902 | DOI Listing |
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