Three undescribed solalodine-type glycoalkaloids, named solanigrinoside A-C (1-3), and six known compounds (4-9) were isolated from the whole plants of Solanum nigrum. Their structures were elucidated based on analysis of HR-ESI-MS, 1D- and 2D-NMR spectral data, and comparison with those reported in literatures. The solanigrinoside A-C (1-3), solasodine (4), and 3-acetoxysolasodine (5) exhibited cytotoxic effects against LU-1, Hep-G2, and MCF-7 cells with IC values in range from 4.6 μM to 56.2 μM. Compound 2 showed the significant cytotoxic activity with corresponding IC values of 5.7 μM, 7.9 μM, and 4.6 μM, respectively.
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Article Synopsis
- Conventional chemotherapy struggles with drug resistance and side effects in colorectal cancer (CRC), prompting research into natural compounds like Ursolic acid (UA) and Solasodine (Sol) that show promise in anti-tumor activity.
- This study focused on the synergy between UA and Sol in fighting CRC by triggering cell death (apoptosis) and preventing the spread (metastasis) of cancer through specific cellular pathways.
- Results indicated that combining UA and Sol effectively reduced CRC cell viability and promoted cancer cell death by enhancing gene expression related to apoptosis and autophagy, while also inhibiting factors that facilitate cancer spread.
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