AI Article Synopsis

  • * The review discusses factors influencing NCI onset and progression, emphasizing its links to both motor and non-motor symptoms, including mood disorders, and suggests that evaluating these could aid in predicting NCI.
  • * Prompt recognition and management of cognitive complaints in PD are crucial, as NCI can significantly impact patients’ social cognition and overall quality of life.

Article Abstract

In addition to motor symptoms, neurocognitive impairment (NCI) affects patients with prodromal Parkinson's disease (PD). NCI in PD ranges from subjective cognitive complaints to dementia. The purpose of this review is to present the available evidence of NCI in PD and highlight the heterogeneity of NCI phenotypes as well as the range of factors that contribute to NCI onset and progression. A review of publications related to NCI in PD up to March 2023 was performed using PubMed/Medline. There is an interconnection between the neurocognitive and motor symptoms of the disease, suggesting a common underlying pathophysiology as well as an interconnection between NCI and non-motor symptoms, such as mood disorders, which may contribute to confounding NCI. Motor and non-motor symptom evaluation could be used prognostically for NCI onset and progression in combination with imaging, laboratory, and genetic data. Additionally, the implications of NCI on the social cognition of afflicted patients warrant its prompt management. The etiology of NCI onset and its progression in PD is multifactorial and its effects are equally grave as the motor effects. This review highlights the importance of the prompt identification of subjective cognitive complaints in PD patients and NCI management.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11054167PMC
http://dx.doi.org/10.3390/neurolint16020032DOI Listing

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