AI Article Synopsis
- Histone post-translational modifications are key in regulating gene expression and biological processes, but their impact on fungal virulence is not well understood.!
- This study focused on a specific histone methyltransferase, which was found to be important in maintaining fungal virulence and affecting mycotoxin production.!
- The findings suggest that the absence of this methyltransferase leads to reduced virulence and impaired responses to environmental stresses in the fungal strains studied.!
Article Abstract
Histone post-translational modification is one of the main mechanisms of epigenetic regulation, which plays a crucial role in the control of gene expression and various biological processes. However, whether or not it affects fungal virulence in is not clear. In this study, we identified and cloned the histone methyltransferase () in , which encodes a protein containing a typical SET domain. was found to be dynamically expressed during infection. Knockout experiment demonstrated that deletion of reduced the virulence in mutant strains, accompanied by a significant decrease in H3K9 trimethylation levels. Transcriptomic analysis further revealed the downregulation of genes associated with mycotoxins biosynthesis in deletion mutants. Additionally, the absence of affected the fungus's response to oxidative and osmotic, as well as cellular integrity. Together, our results indicate that the H3K9 methyltransferase Dim5 is essential for H3K9 trimethylation, regulating fungal virulence throug mycotoxins biosynthesis, and the response to environmental stresses in .
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11051235 | PMC |
| http://dx.doi.org/10.3390/jof10040271 | DOI Listing |
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