, a biosafe strain widely utilized in bioproduction and fermentation technology, exhibits a robust hydrolytic enzyme secretion system. Therefore, it is frequently employed as a cell factory for industrial enzyme production. Moreover, has the ability to synthesize various secondary metabolites, such as kojic acid and L-malic acid. Nevertheless, the complex secretion system and protein expression regulation mechanism of pose challenges for expressing numerous heterologous products. By leveraging synthetic biology and novel genetic engineering techniques, has emerged as an ideal candidate for constructing cell factories. In this review, we provide an overview of the latest advancements in the application of -based cell factories in industrial production. These studies suggest that metabolic engineering and optimization of protein expression regulation are key elements in realizing the widespread industrial application of cell factories. It is anticipated that this review will pave the way for more effective approaches and research avenues in the future implementation of cell factories in industrial production.
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| http://dx.doi.org/10.3390/jof10040248 | DOI Listing |
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