Discovery of a Novel Chromone Enantiomer and the Precursors of Nonactic Acid from the Coral-Reef-Derived sp. SCSIO 66814.

Mar Drugs

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

Published: April 2024

AI Article Synopsis

  • - Three pairs of enantiomers and one new natural product were isolated from a coral species, along with three known compounds, using advanced analytical techniques like spectroscopic analysis and X-ray diffraction.
  • - Two of the new fatty acids are believed to be intermediates that lead to the formation of biologically active compounds called homononactic and nonactic acids.
  • - The study provides evidence for a possible biosynthetic pathway for nonactic acid, and one compound showed weak activity against DPPH radicals, indicating potential antioxidant properties.

Article Abstract

Three pairs of enantiomers (-)-the new 12-aloesol () and two new fatty acids ( and )-and one new natural product () together three known compounds (-) were isolated from a coral-reef-derived sp. SCSIO 66814. Their structures were determined through extensive spectroscopic analysis, chiral analysis, and single-crystal X-ray diffraction data. Compounds and were presumed to be intermediates for further generating homononactic acid () and nonactic acid, and the latter two molecules were able to act as precursors to form macrotetrolides with remarkable biological activity. The isolation of related precursors, compounds -, provided more evidence to support the proposal of a plausible biosynthetic pathway for nonactic acid and its homologs. Additionally, (+)- exhibited a weak activity against DPPH radicals.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11051294PMC
http://dx.doi.org/10.3390/md22040181DOI Listing

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